(R)-Baclofen

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0796/10
0796/50
(R)-Baclofen | CAS No. 69308-37-8 | GABA-B Receptor Agonists
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Description: Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
Alternative Names: STX 209

Chemical Name: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid

Purity: ≥99%

Product Details
Citations (14)
Supplemental Products
Reviews (1)

Biological Activity

More active enantiomer of (RS)-Baclofen, a selective GABAB agonist.

Racemate also available.

Technical Data

M.Wt:
213.66
Formula:
C10H12ClNO2
Solubility:
Soluble to 20 mM in water with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
69308-37-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (R)-Baclofen

The citations listed below are publications that use Tocris products. Selected citations for (R)-Baclofen include:

14 Citations: Showing 1 - 10

  1. Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
    Authors: Styr Et al.
    Neuron  2019;102:1009
  2. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
    Authors: Chai Et al.
    Neuron  2017;95:531
  3. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.
    Authors: Bragina Et al.
    Front Cell Neurosci  2015;9:345
  4. Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.
    Authors: Wang Et al.
    Mol Cell Neurosci  2015;9:188
  5. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
    Front Cell Neurosci  2015;5:10468
  6. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
    Authors: Kirwan Et al.
    J Pharmacol Exp Ther  2015;142:3178
  7. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One  2014;9:e100968
  8. Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.
    Authors: Messer and Levine
    J Neurosci Res  2012;90:1454
  9. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
    Authors: Klug Et al.
    PLoS One  2012;7:e45323
  10. GABAB receptor-positive modulators: brain region-dependent effects.
    Authors: Hensler Et al.
    J Pharmacol Exp Ther  2012;340:19

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GABAb specific agonist
By Anonymous on 10/22/2018
Application: Species: Mouse

Used to activate GABAb, direct application. Although it did not trigger any response, neither did GABA and this was expected, used it to confirm GABAb is not involved in our assay.


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