(R)-Baclofen

  ( 11 citations )    
Product Datasheet
Catalog Number:0796
Alternate Names:STX 209
Chemical Name:(R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
More active enantiomer of (RS)-Baclofen, a selective GABAB agonist.

Racemate also available.

Technical Data
  • M.Wt:
    213.66
  • Formula:
    C10H12ClNO2
  • Solubility:
    Soluble to 20 mM in water with gentle warming
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    69308-37-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (R)-Baclofen include:

11 Citations: Showing 1 - 10
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  1. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.
    Authors: Bragina Et al.
    Front Cell Neurosci  2015;9:345
  2. Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.
    Authors: Wang Et al.
    Mol Cell Neurosci  2015;9:188
  3. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
    Front Cell Neurosci  2015;5:10468
  4. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
    Authors: Kirwan Et al.
    J Pharmacol Exp Ther  2015;142:3178
  5. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One  2014;9:e100968
  6. Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.
    Authors: Messer and Levine
    J Neurosci Res  2012;90:1454
  7. GABAB receptor-positive modulators: brain region-dependent effects.
    Authors: Hensler Et al.
    J Pharmacol Exp Ther  2012;340:19
  8. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
    Authors: Pacey Et al.
    Sci Rep  2011;338:897
  9. GABAB receptor constituents revealed by tandem affinity purification from transgenic mice.
    Authors: Bartoi Et al.
    J Biol Chem  2010;285:20625
  10. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons.
    Authors: Lobb Et al.
    J Neurophysiol  2010;104:403
  11. Peripheral GABAB agonists stimulate gastric acid secretion in mice.
    Authors: Piqueras and Martínez
    Br J Pharmacol  2004;142:1038
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