Catalog Number: 0796
Alternate Names: STX 209
Chemical Name: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Biological Activity
More active enantiomer of (RS)-Baclofen (Cat. No. 0417), a selective GABAB agonist.
Technical Data
  • M.Wt:
    213.66
  • Formula:
    C10H12ClNO2
  • Solubility:
    Soluble to 20 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    69308-37-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat.
    Hong et al.
    Eur.J.Pharmacol., 1991;196:267
  2. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.
    Falch et al.
    J.Neurochem., 1986;47:898
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (R)-Baclofen include:

10 Citations: Showing 1 - 10
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  1. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.
    Authors: Bragina Et al.
    Front Cell Neurosci 2015;9:345
  2. Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.
    Authors: Wang Et al.
    Mol Cell Neurosci 2015;9:188
  3. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
    Front Cell Neurosci 2015;5:10468
  4. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
    Authors: Kirwan Et al.
    J Pharmacol Exp Ther 2015;142:3178
  5. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One 2014;9:e100968
  6. GABAB receptor-positive modulators: brain region-dependent effects.
    Authors: Hensler Et al.
    J Pharmacol Exp Ther 2012;340:19
  7. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
    Authors: Pacey Et al.
    Sci Rep 2011;338:897
  8. GABAB receptor constituents revealed by tandem affinity purification from transgenic mice.
    Authors: Bartoi Et al.
    J Biol Chem 2010;285:20625
  9. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons.
    Authors: Lobb Et al.
    J Neurophysiol 2010;104:403
  10. Peripheral GABAB agonists stimulate gastric acid secretion in mice.
    Authors: Piqueras and Martínez
    Br J Pharmacol 2004;142:1038
Tocris Small Molecules
Description Application Cat# Citations Images  

(RS)-Baclofen

0417 14  
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