(RS)-Baclofen

  ( 17 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0417
Chemical Name:(RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
Product Details
Citations (17)
Supplemental Products
Reviews
Biological Activity
Selective GABAB receptor agonist. Skeletal muscle relaxant.

R-enantiomer also available.

Technical Data
  • M.Wt:
    213.66
  • Formula:
    C10H12ClNO2
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    1134-47-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (RS)-Baclofen include:

17 Citations: Showing 1 - 10
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  1. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.
    Authors: Doshina Et al.
    Sci Rep  2017;7:370
  2. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    J Neurophysiol  2015;9:115
  3. Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling.
    Authors: Terunuma Et al.
    Front Cell Neurosci  2015;88:74
  4. Developmental changes in synaptic distribution in arcuate nucleus neurons.
    Authors: Baquero Et al.
    Neuropsychopharmacology  2015;35:8558
  5. Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
    Authors: Rubio Et al.
    J Neurosci  2015;35:5625
  6. Baclofen-induced reductions in optional food intake depend upon food composition.
    Authors: Wojnicki Et al.
    Appetite  2013;64:62
  7. Social play behavior in adolescent rats is mediated by functional activity in medial prefrontal cortex and striatum.
    Authors: Kerkhof Et al.
    Neuropsychopharmacology  2013;38:1899
  8. Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
    Authors: Zemoura Et al.
    J Biol Chem  2013;288:34897
  9. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
    Authors: Baloucoune Et al.
    PLoS One  2012;7:e39698
  10. Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
    Authors: Olmos-Serrano Et al.
    Neuropharmacology  2010;30:9929
  11. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci  2010;30:749
  12. Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity.
    Authors: Takesian Et al.
    J Neurosci  2010;30:2716
  13. Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus.
    Authors: Bray and Mynlieff
    Dev Neurobiol  2009;69:885
  14. Co-transmission of dopamine and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    J Neurosci  2008;99:1559
  15. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
    Authors: Petzold Et al.
    J Neurosci  2008;58:897
  16. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
    Authors: Miyazato Et al.
    J Urol  2008;179:1178
  17. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
    Authors: Jakubs Et al.
    Neuron  2006;52:1047
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Average Rating: 5 (Based on 1 review)

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  Excellent
  Mouse Anonymous 03/28/2018
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Summary

Species Mouse

Other Experimental Details

Other Experimental Details Effect was pretty small on striatal dopamine release. This may be due to low expression on terminals.

Please scroll the above reviews for more
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