(RS)-Baclofen

Catalog # Availability Size / Price Qty
0417/1G
(RS)-Baclofen | CAS No. 1134-47-0 | GABA-B Receptor Agonists
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Description: Selective GABAB agonist

Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid

Purity: ≥99%

Product Details
Citations (23)
Supplemental Products
Reviews (1)

Biological Activity

Selective GABAB receptor agonist. Skeletal muscle relaxant.

R-enantiomer also available.

Technical Data

M.Wt:
213.66
Formula:
C10H12ClNO2
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
≥99%
Storage:
Store at RT
CAS No:
1134-47-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies.
    Berthelot et al.
    J.Med.Chem., 1991;34:2557
  2. GABAB receptor pharmacology.
    Bowery et al.
    Annu.Rev.Pharmacol.Toxicol., 1993;33:109
  3. 3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain.
    Hill et al.
    Nature, 1981;290:149

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Citations for (RS)-Baclofen

The citations listed below are publications that use Tocris products. Selected citations for (RS)-Baclofen include:

23 Citations: Showing 1 - 10

  1. Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors.
    Authors: Limó n Et al.
    Transl Psychiatry  2019;9:218
  2. Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings.
    Authors: Vergassola Et al.
    Front Mol Neurosci  2018;11:324
  3. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.
    Authors: Doshina Et al.
    Sci Rep  2017;7:370
  4. Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.
    Authors: Yu Et al.
    Neurobiol Dis  2016;89:23
  5. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    J Neurophysiol  2015;9:115
  6. Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling.
    Authors: Terunuma Et al.
    Front Cell Neurosci  2015;88:74
  7. Developmental changes in synaptic distribution in arcuate nucleus neurons.
    Authors: Baquero Et al.
    Neuropsychopharmacology  2015;35:8558
  8. Context-induced reinstatement of metha. seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
    Authors: Rubio Et al.
    J Neurosci  2015;35:5625
  9. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat
    Authors: Chen Et al.
    J Neurosci  2014;34:9621
  10. Baclofen-induced reductions in optional food intake depend upon food composition.
    Authors: Wojnicki Et al.
    Appetite  2013;64:62
  11. Social play behavior in adolescent rats is mediated by functional activity in medial prefrontal cortex and striatum.
    Authors: Kerkhof Et al.
    Neuropsychopharmacology  2013;38:1899
  12. Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
    Authors: Zemoura Et al.
    J Biol Chem  2013;288:34897
  13. PropF. inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.
    Authors: Yang Et al.
    J Immunol  2013;190:6511
  14. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
    Authors: Baloucoune Et al.
    PLoS One  2012;7:e39698
  15. Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.
    Authors: Won Et al.
    J Neurophysiol  2011;105:442
  16. Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
    Authors: Olmos-Serrano Et al.
    Neuropharmacology  2010;30:9929
  17. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci  2010;30:749
  18. Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity.
    Authors: Takesian Et al.
    J Neurosci  2010;30:2716
  19. Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus.
    Authors: Bray and Mynlieff
    Dev Neurobiol  2009;69:885
  20. Co-transmission of DA and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    J Neurosci  2008;99:1559
  21. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
    Authors: Petzold Et al.
    J Neurosci  2008;58:897
  22. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
    Authors: Miyazato Et al.
    J Urol  2008;179:1178
  23. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
    Authors: Jakubs Et al.
    Neuron  2006;52:1047

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Baclofen effects on dopamine release
By Anonymous on 03/28/2018
Application: Species: Mouse

Effects of GABAB agonism on electrically stimulated dopamine release was measured using fast scan cyclic voltammetry. Baclofen (30uM) was bath applied. This is a maximal concentration.


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