Catalog Number: 0417
Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
Biological Activity
Selective GABAB receptor agonist. Skeletal muscle relaxant. (R)-Baclofen (Cat. No. 0796) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. GABAB receptor pharmacology.
    Bowery et al.
    Annu.Rev.Pharmacol.Toxicol., 1993;33:109
  2. 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies.
    Berthelot et al.
    J.Med.Chem., 1991;34:2557
  3. 3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain.
    Hill et al.
    Nature, 1981;290:149

The citations listed below are publications that use Tocris products. Selected citations for (RS)-Baclofen include:

Showing Results 1 - 10 of 14

  1. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    J Neurophysiol
  2. Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling.
    Authors: Terunuma Et al.
    Front Cell Neurosci
  3. Developmental changes in synaptic distribution in arcuate nucleus neurons.
    Authors: Baquero Et al.
  4. Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
    Authors: Rubio Et al.
    J Neurosci
  5. Baclofen-induced reductions in optional food intake depend upon food composition.
    Authors: Wojnicki Et al.
  6. Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
    Authors: Zemoura Et al.
    J Biol Chem
  7. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
    Authors: Baloucoune Et al.
    PLoS One
  8. Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
    Authors: Olmos-Serrano Et al.
  9. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci
  10. Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity.
    Authors: Takesian Et al.
    J Neurosci
  11. Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus.
    Authors: Bray and Mynlieff
    Dev Neurobiol
  12. Co-transmission of dopamine and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    J Neurosci
  13. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
    Authors: Petzold Et al.
    J Neurosci
  14. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
    Authors: Jakubs Et al.
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