Catalog Number: 0417
Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
Biological Activity
Selective GABAB receptor agonist. Skeletal muscle relaxant.

R-enantiomer also available.

Technical Data
  • M.Wt:
    213.66
  • Formula:
    C10H12ClNO2
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    1134-47-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. GABAB receptor pharmacology.
    Bowery et al.
    Annu.Rev.Pharmacol.Toxicol., 1993;33:109
  2. 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies.
    Berthelot et al.
    J.Med.Chem., 1991;34:2557
  3. 3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain.
    Hill et al.
    Nature, 1981;290:149
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (RS)-Baclofen include:

14 Citations: Showing 1 - 10
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  1. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    J Neurophysiol 2015;9:115
  2. Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling.
    Authors: Terunuma Et al.
    Front Cell Neurosci 2015;88:74
  3. Developmental changes in synaptic distribution in arcuate nucleus neurons.
    Authors: Baquero Et al.
    Neuropsychopharmacology 2015;35:8558
  4. Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
    Authors: Rubio Et al.
    J Neurosci 2015;35:5625
  5. Baclofen-induced reductions in optional food intake depend upon food composition.
    Authors: Wojnicki Et al.
    Appetite 2013;64:62
  6. Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
    Authors: Zemoura Et al.
    J Biol Chem 2013;288:34897
  7. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
    Authors: Baloucoune Et al.
    PLoS One 2012;7:e39698
  8. Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
    Authors: Olmos-Serrano Et al.
    Neuropharmacology 2010;30:9929
  9. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci 2010;30:749
  10. Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity.
    Authors: Takesian Et al.
    J Neurosci 2010;30:2716
  11. Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus.
    Authors: Bray and Mynlieff
    Dev Neurobiol 2009;69:885
  12. Co-transmission of dopamine and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    J Neurosci 2008;99:1559
  13. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
    Authors: Petzold Et al.
    J Neurosci 2008;58:897
  14. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
    Authors: Jakubs Et al.
    Neuron 2006;52:1047
Expand to show all 14 Citations
Tocris Small Molecules
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(R)-Baclofen

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