Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
Biological ActivitySelective GABAB receptor agonist. Skeletal muscle relaxant.
R-enantiomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies.
Berthelot et al.
GABAB receptor pharmacology.
Bowery et al.
3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain.
Hill et al.
Citations for (RS)-Baclofen
The citations listed below are publications that use Tocris products. Selected citations for (RS)-Baclofen include:
23 Citations: Showing 1 - 10
Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors.
Authors: Limó n Et al.
Transl Psychiatry 2019;9:218
Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings.
Authors: Vergassola Et al.
Front Mol Neurosci 2018;11:324
Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.
Authors: Doshina Et al.
Sci Rep 2017;7:370
Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.
Authors: Yu Et al.
Neurobiol Dis 2016;89:23
Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
Authors: Bell Et al.
J Neurophysiol 2015;9:115
Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling.
Authors: Terunuma Et al.
Front Cell Neurosci 2015;88:74
Developmental changes in synaptic distribution in arcuate nucleus neurons.
Authors: Baquero Et al.
Context-induced reinstatement of metha. seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
Authors: Rubio Et al.
J Neurosci 2015;35:5625
Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat
Authors: Chen Et al.
J Neurosci 2014;34:9621
Baclofen-induced reductions in optional food intake depend upon food composition.
Authors: Wojnicki Et al.
Social play behavior in adolescent rats is mediated by functional activity in medial prefrontal cortex and striatum.
Authors: Kerkhof Et al.
Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
Authors: Zemoura Et al.
J Biol Chem 2013;288:34897
PropF. inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.
Authors: Yang Et al.
J Immunol 2013;190:6511
GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
Authors: Baloucoune Et al.
PLoS One 2012;7:e39698
Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.
Authors: Won Et al.
J Neurophysiol 2011;105:442
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
Authors: Olmos-Serrano Et al.
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
Authors: Tu Et al.
J Neurosci 2010;30:749
Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity.
Authors: Takesian Et al.
J Neurosci 2010;30:2716
Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus.
Authors: Bray and Mynlieff
Dev Neurobiol 2009;69:885
Co-transmission of DA and GABA in periglomerular cells.
Authors: Maher and Westbrook
J Neurosci 2008;99:1559
Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
Authors: Petzold Et al.
J Neurosci 2008;58:897
GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
Authors: Miyazato Et al.
J Urol 2008;179:1178
Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
Authors: Jakubs Et al.
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Effects of GABAB agonism on electrically stimulated dopamine release was measured using fast scan cyclic voltammetry. Baclofen (30uM) was bath applied. This is a maximal concentration.