Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e]benzoxacyclotetradecin-6,12(7H)-dione
Biological Activity Antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.
Soluble to 25 mM in ethanol
Desiccate at -20°C
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All Tocris products are intended for laboratory research use only.
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