Antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.
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Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90.
Lee et al.
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.
Schulte et al.
Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis.
Oikawa et al.