Catalog Number: 1967
Chemical Name: N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethanediamine hydrochloride
Biological Activity
Potent, selective and competitive histamine H2 receptor antagonist (pA2 = 6.95 - 7.2). Inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food in vivo. Also inhibits aspirin-induced gastric lesions.
Technical Data
  • M.Wt:
    350.86
  • Formula:
    C13H22N4O3S.HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    66357-59-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine.
    Daly et al.
    Br.J.Pharmacol., 1981;72:49
  2. Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog.
    Daly et al.
    Br.J.Pharmacol., 1981;72:55
  3. A review of the animal pharmacology of ranitidine - a new, selective histamine H2-antagonist.
    Brittain and Daly
    Scand.J.Gastroenterol.Suppl., 1981;69:1
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ranitidine hydrochloride include:

1 Citations: Showing 1 - 1

  1. Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia.
    Authors: Kwiatkowski Et al.
    J Exp Biol 2013;216:1827

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