hh Reboxetine mesylate (CAS 98769-84-7): R&D Systems
Catalog Number: 1982
Chemical Name: (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate
Biological Activity
Potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.
Technical Data
  • M.Wt:
    409.5
  • Formula:
    C19H23NO3.CH3SO3H
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    98769-84-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain.
    Sacchetti et al.
    Br.J.Pharmacol., 1999;128:1332
  2. Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor.
    Wong et al.
    Biol.Psychiatry., 2000;47:818
  3. S33005, a novel ligand at both serotonin and norepinephrine transporters: I Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.
    Millan et al.
    J.Pharmacol.Exp.Ther., 2001;298:565
  4. Reboxetine modulates norepinephrine efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors.
    Owen and Whitton
    Neurosci.Lett., 2003;348:171
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Reboxetine mesylate include:

4 Citations: Showing 1 - 4
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  1. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects.
    Authors: Munari Et al.
    Neurochem Int 2015;18:pyv045
  2. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
    Authors: Hughes Et al.
    Int J Neuropsychopharmacol 2013;154:1680
  3. Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.
    Authors: Ferreira Et al.
    Theriogenology 2012;61:219
  4. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
    Authors: Hutchinson Et al.
    Pain 2012;37:321

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