Reboxetine mesylate

Catalog # Availability Size / Price Qty
Reboxetine mesylate | CAS No. 98769-84-7 | Adrenergic Transporter Inhibitors
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Description: Potent and selective noradrenalin uptake inhibitor; orally active

Chemical Name: (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products

Biological Activity

Reboxetine mesylate is a potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

Technical Data

Soluble to 50 mM in water and to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Reboxetine mesylate

The citations listed below are publications that use Tocris products. Selected citations for Reboxetine mesylate include:

9 Citations: Showing 1 - 9

  1. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.
    Authors: Kreiner Et al.
    Sci Rep  2019;9:5262
  2. Cortical bone is an extraneuronal site of norepinephrine uptake in adult mice.
    Authors: Zhu Et al.
    Bone Rep  2018;9:188
  3. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects.
    Authors: Munari Et al.
    Neurochem Int  2015;18:pyv045
  4. Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
    Authors: Suto Et al.
    Pain  2014;155:1935
  5. A translational rodent assay of affective biases in depression and antidepressant therapy.
    Authors: Stuart Et al.
    Neuropsychopharmacology  2013;38:1625
  6. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
    Authors: Hughes Et al.
    Int J Neuropsychopharmacol  2013;154:1680
  7. Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.
    Authors: Ferreira Et al.
    Theriogenology  2012;61:219
  8. Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin.
    Authors: Hutchinson Et al.
    Pain  2012;37:321
  9. Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine.
    Authors: Kobayashi Et al.
    Neuropsychopharmacology  2010;35:1560


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