Catalog Number: 1982
Chemical Name: (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate
Biological Activity
Potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain.
    Sacchetti et al.
    Br.J.Pharmacol., 1999;128:1332
  2. Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor.
    Wong et al.
    Biol.Psychiatry., 2000;47:818
  3. S33005, a novel ligand at both serotonin and norepinephrine transporters: I Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.
    Millan et al.
    J.Pharmacol.Exp.Ther., 2001;298:565
  4. Reboxetine modulates norepinephrine efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors.
    Owen and Whitton
    Neurosci.Lett., 2003;348:171
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