Chemical Name: (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate
Biological ActivityReboxetine mesylate is a potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain.
Sacchetti et al.
Reboxetine: a pharmacologically potent, selective, and specific NE reuptake inhibitor.
Wong et al.
S33005, a novel ligand at both serotonin and NE transporters: I Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.
Millan et al.
Reboxetine modulates NE efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors.
Owen and Whitton
Citations for Reboxetine mesylate
The citations listed below are publications that use Tocris products. Selected citations for Reboxetine mesylate include:
9 Citations: Showing 1 - 9
Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.
Authors: Kreiner Et al.
Sci Rep 2019;9:5262
Cortical bone is an extraneuronal site of norepinephrine uptake in adult mice.
Authors: Zhu Et al.
Bone Rep 2018;9:188
Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects.
Authors: Munari Et al.
Neurochem Int 2015;18:pyv045
Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
Authors: Suto Et al.
A translational rodent assay of affective biases in depression and antidepressant therapy.
Authors: Stuart Et al.
Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
Authors: Hughes Et al.
Int J Neuropsychopharmacol 2013;154:1680
Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.
Authors: Ferreira Et al.
Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin.
Authors: Hutchinson Et al.
Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine.
Authors: Kobayashi Et al.
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Reboxetine mesylate was dissolved in saline serum and 20 mg/kg (100 μL) were administered intraperitoneally to mice. After 24h, brain samples were taken and MCP-1 synthesis was analyzed by immunohistochemistry. This way, we confirmed that reboxetine treatment induces MCP-1 synthesis in cortical astrocytes.