Recombinant Mouse BTNL10/Butyrophilin-like 10 Fc Protein, CF Summary
Accession # Q9JK39
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 200 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||
Recombinant Mouse BTNL10 Fc Chimera (Catalog # 1444-BT)inhibits IL-2 secretion by mouse T cells in the presence of anti-CD3 antibody.The ED50 for this effect is 0.5-2.5 μg/mL.
2 μg/lane of Recombinant Mouse BTNL10 was resolved with SDS-PAGE underreducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Bluestaining, showing bands at 58 - 63 kDa and 120 - 130 kDa, respectively.
Butyrophilin-like 10 (BTNL10) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation (1). Mouse BTNL10 is a 275 amino acid (aa) type I transmembrane glycoprotein that contains a signal peptide followed by an extracellular domain (ECD), a transmembrane region, and a short cytoplasmic domain. The ECD of mouse BTNL10 features a single IgV and a poorly defined IgC domain. The IgV domain of mouse BTNL10 shares 53% and 52% sequence identity with the equivalent domain in human and rat BTNL10, respectively. Although recently identified, BTNL10 is one of only five butyrophilins conserved between human and mouse (2). While the complete immunological function of BTN/BTNL molecules is only beginning to emerge, they have been shown to be important in immunity by regulating T cell function (2-4). Recent efforts have focused on BTN/BTNL as potential therapeutic targets for a wide range of diseases (2-4). Currently, both the expression pattern and native function of BTNL10 remain unknown. Our data indicate that BTNL10 inhibits the human T cell activation, including IL-2, IFN-gamma secretion, and T cell proliferation.
- Arnett, H.A. et al. (2007) J. Immunol. 178:1523.
- Arnett, H.A. et al. (2012) Immunogenetics. 64:781.
- Abeler-Dörner L. et al. (2012) Trends Immunol. 33(1):34.
- Arnett, H.A. and Viney J.L. (2014) Nat Rev Immunol. 14(8):559.
No product specific FAQs exist for this product, however you mayView all Proteins and Enzyme FAQs
Reviews for Recombinant Mouse BTNL10/Butyrophilin-like 10 Fc Protein, CF
There are currently no reviews for this product. Be the first to review Recombinant Mouse BTNL10/Butyrophilin-like 10 Fc Protein, CF and earn rewards!
Have you used Recombinant Mouse BTNL10/Butyrophilin-like 10 Fc Protein, CF?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image