Recombinant Mouse IGSF4C/SynCAM4 Fc Chimera Protein, CF

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Recombinant Mouse IGSF4C/SynCAM4 Fc Chimera Protein Bioactivity
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Recombinant Mouse IGSF4C/SynCAM4 Fc Chimera Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Recombinant Mouse IGSF4C/SynCAM4 Fc Chimera, immobilized at 0.5-1 μg/mL on a 96-well plate, is able to significantly enhance neurite outgrowth.
Mouse myeloma cell line, NS0-derived mouse IGSF4C/SynCAM4 protein
Mouse IGSF4C
Accession # Q8R464
Accession #
N-terminal Sequence
No results obtained. Gln25 inferred from enzymatic pyroglutamate treatment revealing Glu26.
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
60 kDa
81-93 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 1 mg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
  • 12 months from date of receipt, ≤ -20 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse IGSF4C/SynCAM4 Fc Chimera Protein Bioactivity View Larger

Recombinant Mouse IGSF4C/SynCAM4 Fc Chimera (Catalog # 9906-S4) Induces Cortical Neurite Outgrowth. A) Untreated E16-18 embryonic rat cortical neurons. B) Neurite outgrowth in E16-18 embryonic rat cortical neurons treated with 0.5 μg/mL of Recombinant Mouse IGSF4C/SynCAM4 Fc Chimera.

SDS-PAGE Recombinant Mouse IGSF4C/SynCAM4 Fc Chimera Protein SDS-PAGE View Larger

2 μg/lane of Recombinant Mouse IGSF4C was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 81-93 kDa and 160-190 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: IGSF4C/SynCAM4

IGSF4C is an immunoglobulin superfamily member that is also known as Nectin-like protein 4 (Necl-4), synaptic cell adhesion molecule 4 (SynCAM4), or tumor suppressor in lung cancer-like 2 (TSLL-2) (1, 2). The four IGSF4 proteins, designated A, B, C and D, are type I transmembrane glycoproteins expressed mainly in neurons, but also in lung, kidney, bladder, prostate and testis (1-5). Each contain one V-type Ig-like and two C2-type Ig-like domains. These domains are responsible for Ca++-independent homophilic and heterophilic interactions. The 388  a mouse IGSF4C contains a 24 aa signal sequence, a 300 aa ECD that shares 99% amino acid (aa) identity with rat and human IGSF4C, a 21 aa transmembrane sequence, and a 43 aa cytoplasmic domain. The apparent size of mouse or human IGSF4C may be variably reported as 48-67 kDa, probably due to differences in glycosylation (2, 5, 6). In the peripheral nervous system, IGSF4C is expressed on Schwann cells, and its internodal interaction with IGSF4A (Necl-1, SynCAM-3) on axons is critical for adhesion and myelination (6-8). In the brain, all IGSF4 family members are expressed at high levels concurrent with synapse formation (4). In the cerebellum, IGSF4C is expressed on Purkinje cells, with complementary expression of IGSF4 on granule cells (4). Heterophilic interaction with IGSF4D (Necl-3, SynCAM2) has also been identified, but homophilic interaction is unlikely (4, 7). IGSF4C is also proposed as a tumor suppressor that is down-regulated in many prostate cancers and gliomas (1, 5).

  1. Fukuhara, H. et al. (2001) Oncogene 20:5401.
  2. Biederer, T. et al. (2006) Genomics 87:139.
  3. Takai, Y. et al. (2008) Nat. Rev. Mol. Cell Biol. 9:603.
  4. Thomas, L. A. et al. (2008) J. Comp. Neurol. 510:47.
  5. Williams, Y. N. et al. (2005) Oncogene 25:1446.
  6. Maurel, P. et al. (2007) J. Cell Biol. 178:861.
  7. Fogel, A. I. et al. (2007) J. Neurosci. 27:12516.
  8. Spiegel, I. et al. (2007) Nat. Neurosci. 10:861.
Long Name
Immunoglobulin Superfamily, Member 4B
Entrez Gene IDs
199731 (Human); 260299 (Mouse)
Alternate Names
CADM4; cell adhesion molecule 4; IGSF4C; IGSF4Cnectin-like 4; Immunoglobulin superfamily member 4C; immunoglobulin superfamily, member 4C; Necl-4; NECL4synCAM4; Nectin-like protein 4; SynCAM4; TSLC1-like 2; TSLC1-like protein 2; TSLL2; TSLL2SynCAM4


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