Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Biological ActivityRisperidone is an atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).
Deuterated analog also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity.
Leysen et al.
Biochemical profile of risperidone, a new antipsychotic.
Leysen et al.
Risperidone: a novel antipsychotic with many "atypical" properties.
Stathis et al.
Structure of the D2 DA receptor bound to the atypical antipsychotic drug risperidone
Wang et al.
Citations for Risperidone
The citations listed below are publications that use Tocris products. Selected citations for Risperidone include:
2 Citations: Showing 1 - 2
Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
Authors: Canfrán-Duque Et al.
Sci Rep 2015;10:e0141829
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Authors: Kurita Et al.
Nat Neurosci 2012;15:1245
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Risperidone
Average Rating: 4 (Based on 1 Review)
Have you used Risperidone?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
We found that risperidone treatment decreased hyperactivity of NF-kappa B p50 subunit KO mice, but had no effect on defective social interaction. Altogether, these data add complexity to a growing body of data, suggesting a link between dysregulation of the NF-kappa B pathway and neurodevelopmental disorders pathogenesis.