Catalog # Availability Size / Price Qty
Risperidone | CAS No. 106266-06-2 | 5-HT2A Receptor Antagonists
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Description: 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names: R 64 766

Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Risperidone is an atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).

Deuterated analog also available.

Technical Data

Soluble to 10 mM in DMSO and to 10 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity.
    Leysen et al.
    J.Clin.Psychiatry, 1994;55:5
  2. Biochemical profile of risperidone, a new antipsychotic.
    Leysen et al.
    J.Pharmacol.Exp.Ther., 1988;247:661
  3. Risperidone: a novel antipsychotic with many "atypical" properties.
    Stathis et al.
    Psychopharmacol., 1996;127:181
  4. Structure of the D2 DA receptor bound to the atypical antipsychotic drug risperidone
    Wang et al.
    Nature, 2018;555:269

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Citations for Risperidone

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2 Citations: Showing 1 - 2


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Risperidone effects in mice hyperactivity
By Anonymous on 01/11/2019
Application: Species: Mouse

We found that risperidone treatment decreased hyperactivity of NF-kappa B p50 subunit KO mice, but had no effect on defective social interaction. Altogether, these data add complexity to a growing body of data, suggesting a link between dysregulation of the NF-kappa B pathway and neurodevelopmental disorders pathogenesis.

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