Catalog Number: 2865
Alternate Names: R 64 766
Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Biological Activity
Atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).

Deuterated analog also available.

Technical Data
  • M.Wt:
    410.48
  • Formula:
    C23H27FN4O2
  • Solubility:
    Soluble to 10 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    106266-06-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.
    Leysen et al.
    J.Clin.Psychiatry, 1994;55:5
  2. Biochemical profile of risperidone, a new antipsychotic.
    Leysen et al.
    J.Pharmacol.Exp.Ther., 1988;247:661
  3. Risperidone: a novel antipsychotic with many "atypical" properties.
    Stathis et al.
    Psychopharmacol., 1996;127:181
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Risperidone include:

1 Citations: Showing 1 - 1

  1. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
    Authors: Canfrán-Duque Et al.
    Sci Rep 2015;10:e0141829
Tocris Small Molecules
Description Application Cat# Citations Images  

Risperidone - d4

5538  
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