Catalog Number: 1955
Chemical Name: 6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Biological Activity
Potent and long-acting 5-HT2 receptor antagonist (Ki = 0.39 nM). Anxiolytic in vivo.
Technical Data
  • M.Wt:
    477.57
  • Formula:
    C27H25F2N3OS
  • Solubility:
    Soluble to 25 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    87051-43-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacology of potent and selective S2-serotonergic antagonists.
    Janssen
    J.Cardiovasc.Pharmacol., 1985;7:S2
  2. Receptor-binding properties in vitro and in vivo of ritanserin.
    Leysen et al.
    Mol.Pharmacol., 1985;27:600
  3. Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives.
    Watanabe et al.
    J.Med.Chem., 1992;35:189
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ritanserin include:

3 Citations: Showing 1 - 3
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  1. The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
    Authors: Bracha Et al.
    Physiol Behav 2013;9:251
  2. Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons.
    Authors: Mondal Et al.
    PLoS One 2013;8:e60365
  3. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
    Authors: Jahchan Et al.
    Cancer Discov 2013;3:1364

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