Ro 19-4603

Catalog # Availability Size / Price Qty
1995/10
1995/50
Ro 19-4603 | CAS No. 99632-94-7 | Benzodiazepine Inverse Agonists
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Description: Benzodiazepine inverse agonist

Chemical Name: 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester

Purity: ≥99%

Product Details
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Biological Activity

Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.

Technical Data

M.Wt:
319.38
Formula:
C15H17N3O3S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
99632-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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