Catalog Number: 2993
Alternate Names: MT 500
Chemical Name: 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine hydrochloride
Biological Activity
High affinity 5-HT2B receptor antagonist (pKi = 9.5). Displays 1000-fold selectivity for 5-HT2B with good bioavailability.
Technical Data
  • M.Wt:
    317.79
  • Formula:
    C17H16FN3.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    199864-86-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist.
    Bonhaus et al.
    Br.J.Pharmacol., 1999;127:1075
  2. Evidence for a control of plasma serotonin levels by 5-Hydroxytryptamine2B receptors in mice.
    Callebert et al.
    J.Pharmacol.Exp.Ther., 2006;317:724
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RS 127445 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells.
    Authors: Tanaka Et al.
    J Biol Chem 2014;289:10466
  2. Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-β/δ in osteoblasts.
    Authors: Chabbi-Achengli Et al.
    PLoS One 2013;8:e75783
  3. Identification of new genes involved in human adipogenesis and fat storage.
    Authors: Söhle Et al.
    PLoS One 2012;7:e31193

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