RS 127445 hydrochloride

Tocris Bioscience | Catalog # 2993

High affinity and selective 5-HT2B antagonist
Tocris Bioscience

Key Product Details

Description

High affinity and selective 5-HT2B antagonist

Alternative Names

MT 500
View all 5-HT2B Receptor Antagonists »

Product Description

RS 127445 hydrochloride is a high affinity 5-HT2B receptor antagonist (pKi = 9.5). Displays 1000-fold selectivity for 5-HT2B with good bioavailability.

Product Specifications for RS 127445 hydrochloride

Molecular Weight

317.79

Formula

C17H16FN3.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine hydrochloride

CAS Number

199864-86-3

PubChem ID

9905058

InChI Key

MKJPYBJBPRFMHL-UHFFFAOYSA-N

SMILES

FC1=C(C=CC=C2)C2=C(C3=CC(C(C)C)=NC(N)=N3)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.78 100
Ethanol 31.78 100

Preparing Stock Solutions for RS 127445 hydrochloride

The following data is based on the product molecular weight 317.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.73 mL 31.47 mL
5 mM 0.63 mL 3.15 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.15 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for RS 127445 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RS 127445 hydrochloride

For research use only

Citations for RS 127445 hydrochloride

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