S 32212 hydrochloride

Key Product Details

Product Description

S 32212 hydrochloride is an inverse agonist of 5-HT_2C receptors (pK_i = 8.18 at human 5-HT_{2C INI} receptors). Also an antagonist of human α₂-adrenoceptors. Displays negligible affinity for α_1A-adrenoceptors, histamine H₁ receptors and muscarinic M₁ receptors.

Product Specifications for S 32212 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for S 32212 hydrochloride

The following data is based on the product molecular weight 452.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.83 mL	44.15 mL	88.30 mL
1.25 mM	1.77 mL	8.83 mL	17.66 mL
2.5 mM	0.88 mL	4.42 mL	8.83 mL
12.5 mM	0.18 mL	0.88 mL	1.77 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dekeyne S32212, a novel serotonin type 2C receptor inverse agonist/α₂-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization. J.Pharmacol.Exp.Ther. 2012 PMID: 22178753
• Millan S32212, a novel serotonin type 2C receptor inverse agonist/α₂-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization. J.Pharmacol.Exp.Ther. 2012 PMID: 22178752

Product Documents for S 32212 hydrochloride