SB 225002

  ( 9 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2725
Chemical Name:N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
Potent and selective CXCR2 chemokine receptor antagonist (IC50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GROα-mediated calcium mobilization in HL60 cells (IC50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo. Inhibits HIV replication in lymphocytes and macrophages.
Technical Data
  • M.Wt:
    352.14
  • Formula:
    C13H10BrN3O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    182498-32-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 225002 include:

9 Citations: Showing 1 - 9
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  1. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities.
    Authors: Jung Et al.
    Stem Cells Dev  2016;25:1006
  2. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.
    Authors: Grabner Et al.
    PLoS One  2015;6:6285
  3. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
    Authors: Lourenco Et al.
    J Immunol  2015;194:3463
  4. CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer.
    Authors: Devapatla Et al.
    Stem Cells Transl Med  2015;10:e0139237
  5. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.
    Authors: Raccosta Et al.
    J Exp Med  2013;210:1711
  6. Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation.
    Authors: Yuen Et al.
    J Clin Invest  2012;1:921
  7. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.
    Authors: Toh Et al.
    PLoS Biol  2011;9:e1001162
  8. CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions.
    Authors: Jang Et al.
    Sci Rep  2011;121:1397
  9. IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo.
    Authors: Lavoie-Lamoureux Et al.
    Am J Physiol Lung Cell Mol Physiol  2010;299:L472

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Average Rating: 4 (Based on 1 review)

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