SB 225002

Catalog # Availability Size / Price Qty
SB 225002 | CAS No. 182498-32-4 | Chemokine Receptor Antagonists
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Description: Potent and selective CXCR2 antagonist

Chemical Name: N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea

Purity: ≥99%

Product Details
Citations (12)
Reviews (1)

Biological Activity

SB 225002 is a potent and selective CXCR2 chemokine receptor antagonist (IC50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GROα-mediated calcium mobilization in HL60 cells (IC50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo. Inhibits HIV replication in lymphocytes and macrophages.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

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Citations for SB 225002

The citations listed below are publications that use Tocris products. Selected citations for SB 225002 include:

12 Citations: Showing 1 - 10

  1. Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis.
    Authors: Karim Et al.
    Sci Rep  2019;9:503
  2. Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment.
    Authors: Chen Et al.
    Cancers (Basel)  2019;11
  3. Chemokine CXCL1 is responsible for cocaine-induced reward in mice.
    Authors: Saika
    NeurosciPharm Reports  2018;38(3):145
  4. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities.
    Authors: Jung Et al.
    Stem Cells Dev  2016;25:1006
  5. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.
    Authors: Grabner Et al.
    PLoS One  2015;6:6285
  6. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
    Authors: Lourenco Et al.
    J Immunol  2015;194:3463
  7. CXCR2 Inhibition Combined with sora. Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer.
    Authors: Devapatla Et al.
    Stem Cells Transl Med  2015;10:e0139237
  8. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.
    Authors: Raccosta Et al.
    J Exp Med  2013;210:1711
  9. Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation.
    Authors: Yuen Et al.
    J Clin Invest  2012;1:921
  10. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.
    Authors: Toh Et al.
    PLoS Biol  2011;9:e1001162


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SB 225002
By Anonymous on 08/22/2016

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