SCH 50911

Key Product Details

Product Description

SCH 50911 is a selective, competitive and orally active GABA_B antagonist. Displays an IC₅₀ of 1.1 μM at GABA_B, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABA_A at concentrations up to 100 μM.

Licensing Information

Sold with the permission of Schering Plough Corporation

Product Specifications for SCH 50911

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SCH 50911

The following data is based on the product molecular weight 173.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.77 mL	28.87 mL	57.73 mL
5 mM	1.15 mL	5.77 mL	11.55 mL
10 mM	0.58 mL	2.89 mL	5.77 mL
50 mM	0.12 mL	0.58 mL	1.15 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 117 publications citing the usage of this product.

• Blythin Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABA_B antagonists. Bioorg.Med.Chem.Lett.
• Hosford Characterization of the antiabsence effects of SCH 50911, a GABA_B receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 1995 PMID: 7562514
• Ong The morpholino-acetic acid analogue Sch 50911 is a selective GABA_B receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 1998 PMID: 9865527
• Bolser The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 1995 PMID: 7562513

Product Documents for SCH 50911