SCH 50911

  ( 9 citations )    
Product Datasheet
Catalog Number:0984
Chemical Name:(2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
A selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 μM.
Technical Data
  • M.Wt:
    173.21
  • Formula:
    C8H15NO3
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in phosphate buffered saline
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    733717-87-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Schering Plough Corporation
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SCH 50911 include:

9 Citations: Showing 1 - 9
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  1. Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
    Authors: Kreye Et al.
    Brain  2016;139:2641
  2. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
    Authors: Jaiswal Et al.
    J Psychopharmacol  2015;9:127
  3. The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors.
    Authors: Ding Et al.
    Br J Pharmacol  2015;29:725
  4. Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity.
    Authors: Kitagawa Et al.
    Mol Syst Biol  2009;5:280
  5. Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.
    Authors: Fritsch Et al.
    Neuroscience  2009;163:415
  6. Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala.
    Authors: Gryder Et al.
    Toxins (Basel)  2005;94:1728
  7. Ligand-induced signal transduction within heterodimeric GABA(B) receptor.
    Authors: Margeta-Mitrovic Et al.
    Front Cell Neurosci  2001;98:14643
  8. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    J Neurochem  2000;131:1050
  9. Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus.
    Authors: Vogt and Nicoll
    Proc Natl Acad Sci U S A  1999;96:1118

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