Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinic acid
Biological ActivityCGP 35348 is a selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat.
Hao et al.
CGP 35348: a centrally active blocker of GABAB receptors.
Olpe et al.
GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.
Staubli et al.
Involvement of GABAB receptors in convulsant-induced epileptiform activity in rat neocortex in vitro.
Sutor and Luhmann
Citations for CGP 35348
The citations listed below are publications that use Tocris products. Selected citations for CGP 35348 include:
11 Citations: Showing 1 - 10
Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
Authors: Zhao Et al.
The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
Authors: Huang Et al.
Br J Pharmacol 2015;10:413
Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
Authors: Xia Et al.
PLoS One 2014;9:e100968
TRPA1 is essential for the vascular response to environmental cold exposure.
Authors: Aubdool Et al.
Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA DA neurons.
Authors: Vashchinkina Et al.
Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor.
Authors: Gantz Et al.
Cell Metab 2013;78:807
Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation.
Authors: Lecrux Et al.
J Neurosci 2011;31:9836
Loss of Mecp2 in substantia nigra DA neurons compromises the nigrostriatal pathway.
Authors: Gantz Et al.
J Neurosci 2011;31:12629
Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses.
Authors: Gaier Et al.
J Neurosci 2010;30:13656
Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).
Authors: Milenković Et al.
J Neurophysiol 2007;98:1634
The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
Authors: Wood Et al.
Nat Commun 2000;131:1050
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