CGP 35348

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CGP 35348 | CAS No. 123690-79-9 | GABA-B Receptor Antagonists
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Description: Selective GABAB antagonist; brain penetrant

Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinic acid

Product Details
Citations (11)
Supplemental Products

Biological Activity

CGP 35348 is a selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Novartis Pharma AG

Product Datasheets

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Citations for CGP 35348

The citations listed below are publications that use Tocris products. Selected citations for CGP 35348 include:

11 Citations: Showing 1 - 10

  1. Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
    Authors: Zhao Et al.
    iScience  2018;6:138
  2. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Br J Pharmacol  2015;10:413
  3. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One  2014;9:e100968
  4. TRPA1 is essential for the vascular response to environmental cold exposure.
    Authors: Aubdool Et al.
    Neuron  2014;5:5732
  5. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA DA neurons.
    Authors: Vashchinkina Et al.
    Neuropsychopharmacology  2014;39:727
  6. Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor.
    Authors: Gantz Et al.
    Cell Metab  2013;78:807
  7. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation.
    Authors: Lecrux Et al.
    J Neurosci  2011;31:9836
  8. Loss of Mecp2 in substantia nigra DA neurons compromises the nigrostriatal pathway.
    Authors: Gantz Et al.
    J Neurosci  2011;31:12629
  9. Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses.
    Authors: Gaier Et al.
    J Neurosci  2010;30:13656
  10. Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).
    Authors: Milenković Et al.
    J Neurophysiol  2007;98:1634


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