CGP 35348

Key Product Details

Product Description

CGP 35348 is a selective, brain penetrant GABA_B receptor antagonist (IC₅₀ = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Licensing Information

Sold with the permission of Novartis Pharma AG

Product Specifications for CGP 35348

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CGP 35348

The following data is based on the product molecular weight 225.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.44 mL	22.20 mL	44.40 mL
5 mM	0.89 mL	4.44 mL	8.88 mL
10 mM	0.44 mL	2.22 mL	4.44 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 113 publications citing the usage of this product.

• Sutor and Luhmann Involvement of GABA_B receptors in convulsant-induced epileptiform activity in rat neocortex in vitro. Eur.J.Neurosci. 1998 PMID: 9824455
• Olpe CGP 35348: a centrally active blocker of GABA_B receptors. Eur.J.Pharmacol. 1990 PMID: 2176979
• Staubli GABA_B receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 1999 PMID: 10341258
• Hao Intrathecal γ-aminobutyric acid_B (GABA_B) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat. Neurosci.Lett. 1994 PMID: 7715832

Product Documents for CGP 35348