CGP 35348

  ( 9 citations )    
Product Datasheet
Catalog Number:1245
Chemical Name:(3-Aminopropyl)(diethoxymethyl)phosphinic acid
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
Selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
Technical Data
  • M.Wt:
    225.22
  • Formula:
    C8H20NO4P
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    123690-79-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 35348 include:

9 Citations: Showing 1 - 9
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  1. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Br J Pharmacol  2015;10:413
  2. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One  2014;9:e100968
  3. TRPA1 is essential for the vascular response to environmental cold exposure.
    Authors: Aubdool Et al.
    Neuron  2014;5:5732
  4. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons.
    Authors: Vashchinkina Et al.
    Neuropsychopharmacology  2014;39:727
  5. Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor.
    Authors: Gantz Et al.
    Cell Metab  2013;78:807
  6. Pyramidal neurons are eurogenic hubs in the neurovascular coupling response to whisker stimulation.
    Authors: Lecrux Et al.
    J Neurosci  2011;31:9836
  7. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway.
    Authors: Gantz Et al.
    J Neurosci  2011;31:12629
  8. Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).
    Authors: Milenković Et al.
    J Neurophysiol  2007;98:1634
  9. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    Nat Commun  2000;131:1050

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