Catalog Number: 1245
Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinic acid
Biological Activity
Selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Background References
  1. Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat.
    Hao et al.
    Neurosci.Lett., 1994;182:299
  2. Involvement of GABAB receptors in convulsant-induced epileptiform activity in rat neocortex in vitro.
    Sutor and Luhmann
    Eur.J.Neurosci., 1998;10:3417
  3. GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.
    Staubli et al.
    J.Neurosci., 1999;19:4609
  4. CGP 35348: a centrally active blocker of GABAB receptors.
    Olpe et al.
    Eur.J.Pharmacol., 1990;187:27
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