Catalog Number: 1245
Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinic acid
Biological Activity
Selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Background References
  1. Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat.
    Hao et al.
    Neurosci.Lett., 1994;182:299
  2. Involvement of GABAB receptors in convulsant-induced epileptiform activity in rat neocortex in vitro.
    Sutor and Luhmann
    Eur.J.Neurosci., 1998;10:3417
  3. GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.
    Staubli et al.
    J.Neurosci., 1999;19:4609
  4. CGP 35348: a centrally active blocker of GABAB receptors.
    Olpe et al.
    Eur.J.Pharmacol., 1990;187:27

The citations listed below are publications that use Tocris products. Selected citations for CGP 35348 include:

7 Citations: Showing 1 - 7
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  1. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Br J Pharmacol 2015;10:413
  2. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One 2014;9:e100968
  3. TRPA1 is essential for the vascular response to environmental cold exposure.
    Authors: Aubdool Et al.
    Neuron 2014;5:5732
  4. Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor.
    Authors: Gantz Et al.
    Cell Metab 2013;78:807
  5. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway.
    Authors: Gantz Et al.
    J Neurosci 2011;31:12629
  6. Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).
    Authors: Milenković Et al.
    J Neurophysiol 2007;98:1634
  7. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    Nat Commun 2000;131:1050

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