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SCS | CAS No. 3232-36-8 | GABA-A Receptor Antagonists
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Description: Potent GABAA antagonist; β1-subunit selective

Chemical Name: Salicylidene salicylhydrazide

Product Details
Citations (2)

Biological Activity

SCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.

Technical Data

Soluble to 50 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors.
    Thompson et al.
    Br.J.Pharmacol., 2004;142:97

Product Datasheets

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SCS

The citations listed below are publications that use Tocris products. Selected citations for SCS include:

2 Citations: Showing 1 - 2

  1. Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes.
    Authors: Villumsen Et al.
    Proc Natl Acad Sci U S A  2015;16:8
  2. Loss of functional GABA(A) receptors in the Alzheimer diseased brain.
    Authors: Limon Et al.
    J Leukoc Biol  2012;109:10071


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