Chemical Name: Salicylidene salicylhydrazide
Biological ActivitySCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors.
Thompson et al.
Citations for SCS
The citations listed below are publications that use Tocris products. Selected citations for SCS include:
2 Citations: Showing 1 - 2
Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes.
Authors: Villumsen Et al.
Proc Natl Acad Sci U S A 2015;16:8
Loss of functional GABA(A) receptors in the Alzheimer diseased brain.
Authors: Limon Et al.
J Leukoc Biol 2012;109:10071
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