Catalog Number: 2143
Chemical Name: Salicylidene salicylhydrazide
Biological Activity
Potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.
Technical Data
  • M.Wt:
    256.26
  • Formula:
    C14H12N2O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    3232-36-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors.
    Thompson et al.
    Br.J.Pharmacol., 2004;142:97
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SCS include:

2 Citations: Showing 1 - 2
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  1. Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes.
    Authors: Villumsen Et al.
    Proc Natl Acad Sci U S A 2015;16:8
  2. Loss of functional GABA(A) receptors in the Alzheimer diseased brain.
    Authors: Limon Et al.
    J Leukoc Biol 2012;109:10071

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