Chemical Name: N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
Biological ActivitySelective neuropeptide S receptor (NPSR) antagonist (IC50 values are 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively). Displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain.
Okamura et al.
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).
Trapella et al.
Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.
Okamura et al.
Citation for SHA 68
The citations listed below are publications that use Tocris products. Selected citations for SHA 68 include:
1 Citation: Showing 1 - 1
Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies.
Authors: Ruzza Et al.
Pharmacol Res Perspect 2018;6:e00445
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