Siglec-7/CD328 Antibody (6-434) [Alexa Fluor™ Plus 647]

Novus Biologicals | Catalog # NBP2-37732AFP647

Clone 6-434 was used by HLDA to establish CD designation.
Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, CyTOF-ready

Label

Alexa Fluor Plus 647

Antibody Source

Monoclonal Mouse IgG1 Clone # 6-434
View all Siglec-7/CD328 Primary Antibodies »

Product Specifications

Immunogen

Human dendritic cells.

Specificity

The mouse monoclonal antibody 6-434 recognizes CD328 (Siglec-7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes. HLDA 8; WS Code ARN-80652

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Siglec-7/CD328 Antibody (6-434) [Alexa Fluor™ Plus 647]

Application
Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Siglec-7/CD328

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds toalpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyllactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked bycis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptorupon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) thatblock signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killercells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towardsmyelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)

Long Name

Sialic Acid Binding Ig-like Lectin 7

Alternate Names

AIRM1, CD328, QA79, Siglec7

Gene Symbol

SIGLEC7

Additional Siglec-7/CD328 Products

Product Documents for Siglec-7/CD328 Antibody (6-434) [Alexa Fluor™ Plus 647]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Siglec-7/CD328 Antibody (6-434) [Alexa Fluor™ Plus 647]



This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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