Hematopoietic Stem Cell Differentiation Pathways & Lineage-specific Markers

Click on a cell type below to view a subset of molecules used as markers for the identification of that cell type.

Self-renewal
factors
Self-renewal
factors
Self-renewal
inhibitors
Self-renewal
inhibitors
Hematopoietic
Stem Cells
Hematopoietic
Stem Cells
IL-7
IL-7
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Common Lymphoid
Progenitor Cells
Common Lymphoid
Progenitor Cells
IL-7
IL-7
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IL-2
IL-2
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Notch
Notch
T Cells
T Cells
IL-15
IL-15
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Natural Killer
Cells
Natural Killer
Cells
Human B Cell
Expansion Kit
Human B Cell
Expansion Kit
IL-3
IL-3
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IL-4
IL-4
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IL-7
IL-7
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B Cells
B Cells
Flt-3
Ligand
Flt-3
Ligand
Dendritic
Cells
Dendritic
Cells
IL-3
IL-3
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GM-CSF
GM-CSF
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M-CSF
M-CSF
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Common Myeloid
Progenitor Cells
Common Myeloid
Progenitor Cells
Flt-3 Ligand
Flt-3 Ligand
GM-CSF
GM-CSF
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TNF-alpha
TNF-alpha
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GM-CSF
GM-CSF
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Granulocyte-Macrophage
Progenitor Cells
Granulocyte-Macrophage
Progenitor Cells
GM-CSF
GM-CSF
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M-CSF
M-CSF
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Monocytes
Monocytes
GM-CSF
GM-CSF
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Myeloblasts
Myeloblasts
Human Monocyte-
derived DC
Differentiation Kit
Human Monocyte-
derived DC
Differentiation Kit
Flt-3 Ligand
Flt-3 Ligand
GM-CSF
GM-CSF
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IFN-alpha
IFN-alpha
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IL-4
IL-4
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Monocyte-derived
Dendritic Cells
Monocyte-derived
Dendritic Cells
IFN-gamma
IFN-gamma
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IL-6
IL-6
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IL-10
IL-10
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M-CSF
M-CSF
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Macrophages
Macrophages
G-CSF
G-CSF
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GM-CSF
GM-CSF
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IL-6
IL-6
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SCF
SCF
Neutrophils
Neutrophils
GM-CSF
GM-CSF
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IL-3
IL-3
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IL-5
IL-5
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Eosinophils
Eosinophils
G-CSF
G-CSF
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GM-CSF
GM-CSF
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IL-3
IL-3
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Basophils
Basophils
IL-3
IL-3
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SCF
SCF
Tpo
Tpo
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Megakaryocyte-Erythroid
Progenitor Cells
Megakaryocyte-Erythroid
Progenitor Cells
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Erythropoietin
Erythropoietin
Erythrocytes
Erythrocytes
IL-3
IL-3
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IL-6
IL-6
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SCF
SCF
Tpo
Tpo
Megakaryocytes
Megakaryocytes
IL-11
IL-11
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Tpo
Tpo
Platelets
Platelets

Overview of Hematopoietic Stem Cells & Lineage-specific Markers

Hematopoietic stem cells (HSCs) are multipotent, self-renewing progenitor cells from which all differentiated blood cell types arise during the process of hematopoiesis. These cells include lymphocytes, granulocytes, and macrophages of the immune system as well as circulating erythrocytes and platelets. Classically, HSCs are thought to differentiate into two lineage-restricted, lymphoid and myelo-erythroid, oligopotent progenitor cells. An alternative, “myeloid-based” model for blood lineage development from HSCs describes a novel intermediary, a common myelo-lymphoid progenitor cell, which has the capacity to generate progeny from both lineages. The mechanisms controlling HSC self-renewal and differentiation are thought to be influenced by a diverse set of cytokines, chemokines, receptors, and intracellular signaling molecules. Differentiation of HSCs is regulated, in part, by growth factors and cytokines including colony-stimulating factors (CSFs) and interleukins (ILs) that activate intracellular signaling pathways. The factors depicted below are known to influence HSC multipotency, proliferation, and lineage commitment. HSCs and their differentiated progeny can be identified by the expression of specific cell surface lineage markers such as cluster of differentiation (CD) proteins and cytokine receptors.

To learn more, please visit our Hematopoietic Stem Cell Molecules Research Area.

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