SJ 1008066

Key Product Details

Product Description

SJ 1008066 is a cell permeable inhibitor of testis-restricted melanoma antigen protein MAGE-A11 (IC₅₀ = 0.13 μM). SJ 1008066 binds to the MAGE homology domain (MHD) and disrupts MAGE-A11:PCF11 interaction. SJ1008066 exhibits no effect on MAGE-A3:AMPKα1 or MAGE-F1:MMS19 interactions in TR-FRET and cell lysate pulldown assays.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Product Specifications for SJ 1008066

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SJ 1008066

The following data is based on the product molecular weight 330.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.13 mL	30.26 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yang Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. Nat.Commun. 2020 PMID: 33004795

Product Documents for SJ 1008066