Ubiquitin Ligase (E3) Inhibitors: Products

"Ubiquitin Ligase (E3) Inhibitors" has 33 results in Products.
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proTAME 

Cell-permeable APC/C inhibitor

MZ 1 

(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells

Lenalidomide 

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

PRT 4165 

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

Nutlin-3 

MDM2 antagonist; inhibits MDM2-p53 interaction

Heclin 

HECT E3 ubiquitin ligase inhibitor

Apcin 

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

VH 298 

High-affinity inhibitor of VHL

dBET1 

(+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo

GS 143 

β-TrCP1 ligase inhibitor

Nutlin 3a 

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

AT 1 

(+)-JQ1 based PROTAC with selectivity for BRD4

TL 12-186 

Multikinase degrading PROTAC

Apcin 

Cell-permeable APC/C Inhibitor

RITA 

MDM2-p53 interaction inhibitor

NSC 66811 

MDM2 antagonist. Disrupts MDM2-p53 interaction

HLI 373 

Hdm2 inhibitor; activates p53-dependent transcription

SMER 3 

Selective inhibitor of E3 ubiquitin ligase

TAME hydrochloride 

Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination

SKPin C1 

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

SZL P1-41 

Selective Skp2 inhibitor; suppresses E3 ligase activity

NAB 2 

Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport

PTC 209 

Bmi-1 inhibitor; antitumor

SP 141 

High affinity MDM2 inhibitor

A01 

High affinity Smurf1 inhibitor; enhances BMP signaling

cis MZ 1 

Negative Control for MZ1

cis VH 298 

Negative control for VH 298

Pomalidomide 

Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic

CM 11 

Homo-PROTAC for self-degradation of pVHL30

CMP 98 

Negative Control for CM 11

TL 13-27 

Negative control for TL 12-186

YH 239-EE 

Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity

Indisulam 

Molecular glue; pre-mRNA splicing modulator
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