Ubiquitin Ligase (E3) Inhibitors: Products

"Ubiquitin Ligase (E3) Inhibitors" has 40 results in Products.
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proTAME

Cell-permeable APC/C inhibitor

MZ 1

(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells

PRT 4165

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

Apcin

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

VH 298

High-affinity inhibitor of VHL

Lenalidomide

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

dBET1

(+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo

Nutlin-3

MDM2 antagonist; inhibits MDM2-p53 interaction

SZL P1-41

Selective Skp2 inhibitor; suppresses E3 ligase activity

GS 143

β-TrCP1 ligase inhibitor

Heclin

HECT E3 ubiquitin ligase inhibitor

cis MZ 1

Negative Control for MZ1

Apcin

Cell-permeable APC/C Inhibitor

RITA

MDM2-p53 interaction inhibitor

NSC 66811

MDM2 antagonist. Disrupts MDM2-p53 interaction

HLI 373

Hdm2 inhibitor; activates p53-dependent transcription

SMER 3

Selective inhibitor of E3 ubiquitin ligase

TAME hydrochloride

Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination

SKPin C1

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

NAB 2

Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport

PTC 209

Bmi-1 inhibitor; antitumor

SP 141

High affinity MDM2 inhibitor

A01

High affinity Smurf1 inhibitor; enhances BMP signaling

Nutlin 3a

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

cis VH 298

Negative control for VH 298

Azido-Thalidomide

Azide-functionalized Thalidomide, 'click' ligand for PROTACs

Pomalidomide

Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic

AT 1

(+)-JQ1 based PROTAC with selectivity for BRD4

CM 11

Homo-PROTAC for self-degradation of pVHL30

CMP 98

Negative Control for CM 11

VH 032, amine hydrochloride

Functionalized VHL ligand for PROTACs

VH 032 - linker 1

VH 032-PEG3-amine

VH 032 - linker 2

VH 032-PEG4-amine

VH 032 - linker 3

VH 032-alkylC4-amine

TC E3 5031

Carboxylic acid-functionalized Thalidomide, Cereblon ligand for PROTACs

Thalidomide - linker 1

Thalidomide-PEG3-ethylamine

Thalidomide - linker 2

Thalidomide-PEG4-ethylamine

Thalidomide - linker 3

Thalidomide-alkylC4-amine

TL 12-186

Multikinase degrading PROTAC

TL 13-27

Negative control for TL 12-186
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