Ubiquitin Ligase (E3) Inhibitors: Products

"Ubiquitin Ligase (E3) Inhibitors" has 38 results in Products.
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proTAME 

Cell-permeable APC/C inhibitor. This is in the process of being discontinued. The new catalog number will be 7734.

CRBN-6-5-5-VHL 

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

MZ 1 

(+)-JQ1 based Degrader (PROTAC®) that selectively degrades BRD4

Lenalidomide 

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

dBET1 

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

CM 11 

Homo-PROTAC® for self-degradation of pVHL30

Nutlin-3 

MDM2 antagonist; inhibits MDM2-p53 interaction

PRT 4165 

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

Apcin 

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Nutlin 3a 

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

Pomalidomide 

Cereblon binder; also TNF-α inhibitor and antiangiogenic

AT 1 

(+)-JQ1 based PROTAC® with selectivity for BRD4

TL 12-186 

Multikinase Degrader (PROTAC®)

Idasanutlin 

Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

Apcin 

Cell-permeable APC/C Inhibitor. This item is in process of being discontinued.

RITA 

MDM2-p53 interaction inhibitor

HLI 373 

Hdm2 inhibitor; activates p53-dependent transcription

SMER 3 

Selective inhibitor of E3 ubiquitin ligase

SZL P1-41 

Selective Skp2 inhibitor; suppresses E3 ligase activity

NAB 2 

Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport

PTC 209 

Bmi-1 inhibitor; antitumor

SP 141 

High affinity MDM2 inhibitor

A01 

High affinity Smurf1 inhibitor; enhances BMP signaling

GS 143 

β-TrCP1 ligase inhibitor

Heclin 

HECT E3 ubiquitin ligase inhibitor

VH 298 

High-affinity inhibitor of VHL

cis VH 298 

Negative control for VH 298

TL 13-27 

Negative control for TL 12-186 (Cat. No. 6524)

YH 239-EE 

Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity

Indisulam 

Molecular glue; pre-mRNA splicing modulator

WS 383 

Potent, selective and reversible DCN1-UBC12 interaction inhibitor

CSN5i-3 

Potent and selective CSN5 (COP9 signalosome) inhibitor

SMIP 004 

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

Nimbolide 

RNF114 inhibitor

EN 219 

Covalent RNF114 ligand

SPOP-i-6lc 

SPOP E3 ubiquitin ligase inhibitor

CSN5i-3-NEG 

Negative control for CSN5i-3 (Cat. No. 7089)

SJ 1008066 

MAGE-A11 inhibitor disrupts MAGE-A11:PCF11 interaction
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