-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50
values are 2.9, 16 and 8.6 μ
M for inhibition of intracellular Na+-dependent 45
uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC50
= 18 μ
M) but minimal activity against NCKX2 and various receptors and ion channels (IC50
> 30 μ
M). Preferentially blocks Ca2+
influx mode and is more selective for NCX isoforms than KB-R7943
(Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50
= 0.63 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative.
Iwamoto et al.
Forefront of Na+/Ca2+ exchanger studies: molecular pharmacology of N+/Ca2+ exchange inhibitors.
The citations listed below are publications that use Tocris products. Selected citations for SN-6 include:
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