SN-6

Key Product Details

Product Description

SN-6 is a selective Na⁺/Ca²⁺-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC₅₀ values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent ⁴⁵Ca²⁺ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC₅₀ = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC₅₀ > 30 μM). Preferentially blocks Ca²⁺ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC₅₀ = 0.63 μM).

Product Specifications for SN-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SN-6

The following data is based on the product molecular weight 402.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.43 mL	24.87 mL
5 mM	0.50 mL	2.49 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 63 publications citing the usage of this product.

• Iwamoto Forefront of Na⁺/Ca²⁺ exchanger studies: molecular pharmacology of N⁺/Ca²⁺ exchange inhibitors. J.Pharmacol.Sci. 2004 PMID: 15359084
• Iwamoto The exchanger inhibitory peptide region-dependent inhibition of Na⁺/Ca²+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol.Pharmacol. 2004 PMID: 15213295

Product Documents for SN-6