SN-6

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SN-6 | CAS No. 415697-08-4 | Na+/Ca2+ Exchanger Inhibitors
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Description: Selective Na+/Ca2+ exchange inhibitor (reverse mode)

Chemical Name: 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester

Purity: ≥99%

Product Details
Citations (8)
Reviews

Biological Activity

Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).

Technical Data

M.Wt:
402.16
Formula:
C20H22N2O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
415697-08-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SN-6

The citations listed below are publications that use Tocris products. Selected citations for SN-6 include:

8 Citations: Showing 1 - 8

  1. Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity.
    Authors: Bastioli Et al.
    Cell Death Dis  2019;10:80
  2. Glutamate as a potential "survival factor" in an in vitro model of neuronal hypoxia/reoxygenationinjury: leading role of the Na+/Ca2+ exchanger.
    Authors: Piccirillo
    Cell Death Dis  2018;9(7):731
  3. Conditional knockout of smooth muscle sodium calcium exchanger type-1 lowers blood pressure and attenuates Angiotensin II-salt hypertension.
    Authors: Wang Et al.
    Sci Signal  2015;3
  4. Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities.
    Authors: Ciapa and Philippe
    PLoS One  2013;8:e66113
  5. Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
    Authors: Wang Et al.
    Cell Cycle  2012;5:ra26
  6. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism.
    Authors: Fu and Pol
    J Neurosci  2010;30:10205
  7. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.
    Authors: Barrientos Et al.
    Mol Pharmacol  2009;76:560
  8. The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction.
    Authors: Pezier Et al.
    J Neurophysiol  2009;101:1151

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