Biological ActivitySNX 482 is a potent and selective, voltage-dependent R-type CaV2.3 calcium channel blocker (IC50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses.
(Modifications: Disulfide bridge between 7 - 21, 14 - 26, 20 - 33)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Interaction of SNX482 with domains III and IV inhibits activation gating of α1E (CaV2.3) calcium channels.
Bourinet et al.
The CaV2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain.
Matthews et al.
Selective peptide antagonist of the class E calcium channel from the venom of the Tarantula Hysterocrates gigas.
Newcomb et al.
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