Biological ActivityPotent and selective, voltage-dependent R-type CaV2.3 calcium channel blocker (IC50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses.
(Modifications: Disulfide bridge between 7 - 21, 14 - 26, 20 - 33)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Interaction of SNX482 with domains III and IV inhibits activation gating of α1E (CaV2.3) calcium channels.
Bourinet et al.
The CaV2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain.
Matthews et al.
Selective peptide antagonist of the class E calcium channel from the venom of the Tarantula Hysterocrates gigas.
Newcomb et al.
Citations for SNX 482
The citations listed below are publications that use Tocris products. Selected citations for SNX 482 include:
7 Citations: Showing 1 - 7
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.
Authors: Smith Et al.
Cell Rep 2018;25:278
Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
PLoS One 2017;12(9):e0184261
σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
Authors: Pan Et al.
Proc Natl Acad Sci U S A 2014;350:290
Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels.
Authors: Brennan Et al.
PLoS One 2013;8:e80294
Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling.
Authors: Goswami Et al.
J Neurosci 2012;32:14294
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
Authors: Grubb and Burrone
J Pharmacol Exp Ther 2010;465:1070
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Authors: Higley and Sabatini
Nat Neurosci 2010;13:958
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