Potent and selective, voltage-dependent R-type CaV
2.3 calcium channel blocker (IC50
= 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ
-fibre-evoked neuronal responses.
(Modifications: Disulfide bridge between 7 - 21, 14 - 26, 20 - 33)
Soluble in water
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Selective peptide antagonist of the class E calcium channel from the venom of the Tarantula Hysterocrates gigas.
Newcomb et al.
Interaction of SNX482 with domains III and IV inhibits activation gating of α1E (CaV2.3) calcium channels.
Bourinet et al.
The CaV2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain.
Matthews et al.
The citations listed below are publications that use Tocris products. Selected citations for SNX 482 include:
Showing Results 1 - 3 of 3