SP 100030

Catalog # Availability Size / Price Qty
5309/10
5309/50
SP 100030 | CAS No. 154563-54-9 | NFkB/IkB Inhibitors
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Description: NF-κB and AP-1 dual inhibitor

Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.

Technical Data

M.Wt:
437.65
Formula:
C14H5ClF9N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
154563-54-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Jurkat T cell inhibition
By Anonymous on 10/28/2021
Species: Human

Used on Jurkat cell line, to inhibit cell activation after stimulation with PMA/PHA, at a dose of 50ng/mL


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