Catalog Number: 5309
Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Biological Activity
Potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.
Technical Data
  • M.Wt:
    437.65
  • Formula:
    C14H5ClF9N3O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    154563-54-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The effect of a T cell-specific NF-κB inhibitor on in vitro cytokine production and collagen-induced arthritis
    Gerlag et al.
    J.Immunol., 2000;165:1652
  2. 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-κB- and AP-1-mediated gene expression identified using solution-phase combinatorial ch
    Sullivan et al.
    J.Med.Chem., 1998;41:413
  3. The AP-1/NF-κB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia.
    Moore-Carrasco et al.
    Int.J.Oncol., 2007;30:1239

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