Inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.
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Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality.
Chan et al.
NAMPT is the cellular target of STF-31-like small-molecule probes.
Adams et al.
ACS Chem.Biol., 2014;9:2247
Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells.
Kropp et al.
Stem Cells Transl.Med., 2015;4:483
The citations listed below are publications that use Tocris products. Selected citations for STF 31 include:
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