Catalog Number: 4484
Chemical Name: 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide
Biological Activity
Inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.
Technical Data
  • M.Wt:
    423.53
  • Formula:
    C23H25N3O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    724741-75-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality.
    Chan et al.
    Sci.Transl.Med., 2011;3:94ra70
  2. NAMPT is the cellular target of STF-31-like small-molecule probes.
    Adams et al.
    ACS Chem.Biol., 2014;9:2247
  3. Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells.
    Kropp et al.
    Stem Cells Transl.Med., 2015;4:483
Citations:

The citations listed below are publications that use Tocris products. Selected citations for STF 31 include:

1 Citations: Showing 1 - 1

  1. Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells.
    Authors: Kropp Et al.
    Mol Cell Biol 2015;4:483

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