Takinib

Catalog # Availability Size / Price Qty
6430/5
6430/25

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Takinib | CAS No. 1111556-37-6 | Other Kinase Inhibitors
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Description: Potent and selective TAK1/MAP3K7 kinase inhibitor

Chemical Name: N1-(1-Propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide

Purity: ≥98%

Product Details
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Biological Activity

Takinib is a potent and selective TAK1/MAP3K7 kinase inhibitor (IC50 = 8.2-9.5 nM). Selective for TAK1 over IRAK4, IRAK1, GCK, CLK2 and MINK1 (IC50 values = 120, 390, 430, 430 and 1900 nM, respectively). Demonstrates weak inhibition at Src and Yes1. Exhibits no inhibition of MAP2K or other MAP3K family members. Induces apoptosis following TNF-α stimulation in in vitro models of rheumatoid arthritis and metastatic breast cancer.

Technical Data

M.Wt:
322.37
Formula:
C18H18N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1111556-37-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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