Catalog Number: 4270
Chemical Name: N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide
Biological Activity
Class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.
    Chou et al.
    J.Biol.Chem., 2008;283:35402
  2. HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.
    Rai et al.
    PLoS ONE, 2008;3:e1958
  3. Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing.
    Xu et al.
    Chem.Biol., 2009;16:980
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