Class I histone deacetylase (HDAC) inhibitor (IC50
values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.
Chou et al.
HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.
Rai et al.
PLoS ONE, 2008;3:e1958
Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing.
Xu et al.