TC-H 106
Discontinued Product
Chemical Name: N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide
Purity: ≥99%
Biological Activity
TC-H 106 is a class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.
Chou et al.
J.Biol.Chem., 2008;283:35402 -
HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.
Rai et al.
PLoS ONE, 2008;3:e1958 -
Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing.
Xu et al.
Chem.Biol., 2009;16:980
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