Chemical Name: N-(Cyclohexylmethyl)-2-[(5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl}thio]acetamide
Biological ActivityNMDA receptor antagonist, selective for GluN1/GluN2A (formally NR1/NR2A) (pIC50 = 5.4) over GluN1/GluN2B (formally NR1/NR2B) containing receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Direct pharmacological monitoring of the developmental switch in NMDAR subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
McKay et al.
Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Bettini et al.
Citations for TCN 213
The citations listed below are publications that use Tocris products. Selected citations for TCN 213 include:
3 Citations: Showing 1 - 3
Sensitivity of N-MthD.-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
Authors: Izumi and Zorumski
Int J Mol Sci 2015;352:267
Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation.
Authors: Prickett Et al.
J Invest Dermatol 2014;134:2390
Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
Authors: McKay Et al.
Br J Pharmacol 2012;166:924
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