Catalog Number: 4163
Chemical Name: N-(Cyclohexylmethyl)-2-[(5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl}thio]acetamide
Biological Activity
NMDA receptor antagonist, selective for NR1/NR2A (pIC50 = 5.4) over NR1/NR2B.
Technical Data
  • M.Wt:
    376.54
  • Formula:
    C18H24N4OS2
  • Solubility:
    Soluble to 75 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    556803-08-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
    Bettini et al.
    J.Pharm.Exp.Ther., 2010;335:644
  2. Direct pharmacological monitoring of the developmental switch in NMDAR subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
    McKay et al.
    Br.J.Pharmacol., 2012;166:924
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TCN 213 include:

2 Citations: Showing 1 - 2
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  1. Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
    Authors: Izumi and Zorumski
    Int J Mol Sci 2015;352:267
  2. Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation.
    Authors: Prickett Et al.
    J Invest Dermatol 2014;134:2390

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