TCN 213
Chemical Name: N-(Cyclohexylmethyl)-2-[(5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl}thio]acetamide
Purity: ≥99%
Biological Activity
TCN 213 is a NMDA receptor antagonist, selective for GluN1/GluN2A (formally NR1/NR2A) (pIC50 = 5.4) over GluN1/GluN2B (formally NR1/NR2B) containing receptors.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Complete Your Experiment
Background References
-
Direct pharmacological monitoring of the developmental switch in NMDAR subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
McKay et al.
Br.J.Pharmacol., 2012;166:924 -
Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Bettini et al.
J.Pharm.Exp.Ther., 2010;335:644
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for TCN 213
The citations listed below are publications that use Tocris products. Selected citations for TCN 213 include:
3 Citations: Showing 1 - 3
-
Sensitivity of N-MthD.-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
Authors: Izumi and Zorumski
Int J Mol Sci 2015;352:267
-
Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation.
Authors: Prickett Et al.
J Invest Dermatol 2014;134:2390
-
Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
Authors: McKay Et al.
Br J Pharmacol 2012;166:924
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for TCN 213
There are currently no reviews for this product. Be the first to review TCN 213 and earn rewards!
Have you used TCN 213?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image