TCN 213

  ( 3 citations )    
Product Datasheet
Catalog Number:4163
Chemical Name:N-(Cyclohexylmethyl)-2-[(5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl}thio]acetamide
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
NMDA receptor antagonist, selective for GluN1/GluN2A (formally NR1/NR2A) (pIC50 = 5.4) over GluN1/GluN2B (formally NR1/NR2B) containing receptors.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data
  • M.Wt:
    376.54
  • Formula:
    C18H24N4OS2
  • Solubility:
    Soluble to 75 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    556803-08-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TCN 213 include:

3 Citations: Showing 1 - 3
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  1. Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
    Authors: Izumi and Zorumski
    Int J Mol Sci  2015;352:267
  2. Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation.
    Authors: Prickett Et al.
    J Invest Dermatol  2014;134:2390
  3. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
    Authors: McKay Et al.
    Br J Pharmacol  2012;166:924

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