TH 1020

Key Product Details

Product Description

TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC₅₀ = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

Product Specifications for TH 1020

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TH 1020

The following data is based on the product molecular weight 453.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	44.10 mL	220.49 mL	440.98 mL
0.25 mM	8.82 mL	44.10 mL	88.20 mL
0.5 mM	4.41 mL	22.05 mL	44.10 mL
2.5 mM	0.88 mL	4.41 mL	8.82 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yan Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 2016 PMID: 26634412

Product Documents for TH 1020