Catalog Number: 2011
Alternate Names: Atomoxetine, LY 139603
Chemical Name: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
Biological Activity
Potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.

Deuterated analog also available.

Technical Data
  • M.Wt:
    291.82
  • Formula:
    C17H21NO.HCl
  • Solubility:
    Soluble to 50 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    82248-59-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.
    Wong et al.
    J.Pharmacol.Exp.Ther., 1982;222:61
  2. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.
    Bymaster et al.
    Neuropsychopharmacology, 2002;27:699
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tomoxetine hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.
    Authors: Achterberg Et al.
    Psychopharmacology (Berl) 2015;35:161
  2. Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
    Authors: Conley Et al.
    J Neurosci 2015;352:53
  3. Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.
    Authors: Finnema Et al.
    Toxins (Basel) 2015;18
  4. Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.
    Authors: Parker Et al.
    Int J Neuropsychopharmacol 2014;231:2671
Tocris Small Molecules
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Tomoxetine - d3 hydrochloride

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