Tomoxetine hydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:2011
Alternate Names:Atomoxetine, LY 139603
Chemical Name:(R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
Potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.

Deuterated analog also available.

Technical Data
  • M.Wt:
    291.82
  • Formula:
    C17H21NO.HCl
  • Solubility:
    Soluble to 50 mM in water with gentle warming
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    82248-59-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tomoxetine hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.
    Authors: Achterberg Et al.
    Psychopharmacology (Berl)  2015;35:161
  2. Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
    Authors: Conley Et al.
    J Neurosci  2015;352:53
  3. Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.
    Authors: Finnema Et al.
    Toxins (Basel)  2015;18
  4. Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.
    Authors: Parker Et al.
    Int J Neuropsychopharmacol  2014;231:2671
  5. Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine.
    Authors: Kobayashi Et al.
    Neuropsychopharmacology  2010;35:1560

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Tocris Small Molecules
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Tomoxetine - d3 hydrochloride

5527  
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VersaClone cDNA Plasmids
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Human SLC6A2/NET (NP_001034) VersaClone cDNA

RDC1112
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Human SLC6A2/NET (NP_001165975) VersaClone cDNA

RDC1141
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