Chemical Name: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
Biological ActivityTomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A new inhibitor of NE uptake devoid of affinity for receptors in rat brain.
Wong et al.
Atomoxetine increases extracellular levels of NE and DA in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.
Bymaster et al.
Citations for Tomoxetine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Tomoxetine hydrochloride include:
5 Citations: Showing 1 - 5
Methylphenidate and atomox. inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.
Authors: Achterberg Et al.
Psychopharmacology (Berl) 2015;35:161
Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
Authors: Conley Et al.
J Neurosci 2015;352:53
Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.
Authors: Finnema Et al.
Toxins (Basel) 2015;18
Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.
Authors: Parker Et al.
Int J Neuropsychopharmacol 2014;231:2671
Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine.
Authors: Kobayashi Et al.
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diluted into saline solution to be injected into animals for observation of behavioral effects