TPCA-1

  ( 8 citations )    
Product Datasheet
Catalog Number:2559
Chemical Name:2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
Product Details
Citations (8)
Reviews
Biological Activity
Potent, selective inhibitor of IκB kinase (IKK) β (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKKα and > 550-fold selectivity over other kinases and enzymes. Inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. Reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.
Technical Data
  • M.Wt:
    279.29
  • Formula:
    C12H10FN3O2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >97
  • Storage:
    Desiccate at -20°C
  • CAS No:
    507475-17-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for TPCA-1 include:

8 Citations: Showing 1 - 8
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  1. A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.
    Authors: Betancur
    Nat Commun  2017;8:14802
  2. NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II.
    Authors: Pescatore Et al.
    Cell Death & Disease  2016;7:e2346
  3. Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions inhuman astrocytes.
    Authors: O'Sullivan Et al.
    Journal of Neuroinflammation  2016;13:189
  4. Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1.
    Authors: Cataldi Et al.
    Virology  2015;485:340
  5. IKK2 Inhibition Using TPCA-1-Loaded PLGA Microparticles Attenuates Laser-Induced Choroidal Neovascularization and Macrophage Recruitment.
    Authors: Gaddipati Et al.
    PLoS One  2015;10:e0121185
  6. IKK2 inhibition attenuates laser-induced choroidal neovascularization.
    Authors: Lu Et al.
    Open Biol  2014;9:e87530
  7. Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.
    Authors: Yi Et al.
    J Biol Chem  2014;289:10853
  8. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms.
    Authors: Rauert Et al.
    Cell Death Dis  2011;2:e194

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