TPCA-1

Catalog # Availability Size / Price Qty
2559/10
TPCA-1 | CAS No. 507475-17-4 | IkB Kinase Inhibitors
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Description: Potent, selective inhibitor of IKKβ

Chemical Name: 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide

Purity: ≥97%

Product Details
Citations (8)
Reviews

Biological Activity

Potent, selective inhibitor of IκB kinase (IKK) β (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKKα and > 550-fold selectivity over other kinases and enzymes. Inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. Reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.

Technical Data

M.Wt:
279.29
Formula:
C12H10FN3O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥97%
Storage:
Desiccate at -20°C
CAS No:
507475-17-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TPCA-1

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8 Citations: Showing 1 - 8

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