Catalog Number: 0761
Alternate Names: Ro 13-7410
Chemical Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Biological Activity
Extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).
Technical Data
  • M.Wt:
    348.48
  • Formula:
    C24H28O2
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    71441-28-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
    Hou et al.
    , 2013;341:651
  2. Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.
    Minucci et al.
    Proc.Natl.Acad.Sci.U.S.A., 1996;93:1803
  3. Arotinoids, a new class of highly active retinoids.
    Loeliger et al.
    Eur.J.Med.Chem.-Chim.Ther., 1980;15:9
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TTNPB include:

3 Citations: Showing 1 - 3
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  1. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
    Authors: Chronopoulos Et al.
    Nature Communications 2016;7:12630
  2. The lymph node as a new site for kidney organogenesis.
    Authors: Francipane and Lagasse
    Stem Cells Transl Med 2015;4:295
  3. Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
    Authors: Thomas and Henry
    Br J Pharmacol 2014;386:291

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