UCH-L1/PGP9.5 Antibody - BSA Free

Novus Biologicals | Catalog # NBP2-24719

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Monkey, Primate

Predicted:

Bovine (96%), Equine (96%), Porcine (96%), Rat (94%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all UCH-L1/PGP9.5 Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 100-150 of human UCH-L1/PGP9.5 was used as the immunogen.

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in chimpanzee & crab-eating macaque

Marker

pan-Neuronal Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UCH-L1/PGP9.5 Antibody - BSA Free

Western Blot: UCH-L1/PGP9.5 Antibody [NBP2-24719]

Western Blot: UCH-L1/PGP9.5 Antibody [NBP2-24719]

Western Blot: UCH-L1/PGP9.5 Antibody [NBP2-24719] - Western blot analysis of extracts from C6 cell using PGP9.5 / UCHL-1 antibody
Western Blot: UCH-L1/PGP9.5 Antibody [NBP2-24719]

Western Blot: UCH-L1/PGP9.5 Antibody [NBP2-24719]

Western Blot: UCH-L1/PGP9.5 Antibody [NBP2-24719] - Analysis of UCH-L1/PGP9.5 in human brain lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse brain lysate and 4) rat brain lysate

Applications for UCH-L1/PGP9.5 Antibody - BSA Free

Application
Recommended Usage

Western Blot

0.1-0.5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS and 0.2% Gelatin

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UCH-L1/PGP9.5

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a soluble cytoplasmic protein found in neurons and in cells of the diffuse neuroendocrine system, and their respective tumors. Therefore, UCH-L1 has been widely used as a peripheral nerve fiber marker. UCHL-1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme involved in the processing of both ubiquitin precursors and ubiquitinated proteins.

UCH L1 is down-regulated in brains from Parkinson disease and Alzheimer disease patients, and certain site specific mutations in the UCHL1 gene can either increase or decrease the risk of Parkinson's and/or Alzheimer's neurodegenerative diseases.

Human UCHL 1 and the closely related UCHL3 protein have one of the most complicated knot structures ever discovered, with five knot crossings. This knot structure is expected to help the protein resist degradation in the proteasome.

Long Name

Ubiquitin C-terminal Hydrolase L1

Alternate Names

PARK5, PGP9.5, UCHL1

Gene Symbol

UCHL1

UniProt

P09936 (Human)

Additional UCH-L1/PGP9.5 Products

Product Documents for UCH-L1/PGP9.5 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for UCH-L1/PGP9.5 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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