Chemical Name: 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
Biological ActivitySelective and potent COX-2 inhibitor (in vitro IC50 values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.
Talley et al.
A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors.
Walker et al.
Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity.
Gierse et al.
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