VH 032 amide-PEG3-BCN

Tocris Bioscience | Catalog # 8123

Functionalized VHL building block for copper-free click chemistry
Tocris Bioscience

Key Product Details

Description

Functionalized VHL building block for copper-free click chemistry
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Product Description

VH 032 amide-PEG3-BCN is a functionalized von Hippel Lindau (VHL) protein ligand for PROTAC® research and development. Incorporates an E3 ligase ligand plus a PEG3 linker with terminal bicyclooctyne (BCN). It can be used for copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for VH 032 amide-PEG3-BCN

Molecular Weight

810.02

Formula

C42H59N5O9S

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate

CAS Number

2876198-36-4

PubChem ID

169450546

InChI Key

WLQVZOBNMRIBKF-LLQRHEORSA-N

SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOCCOCCNC(OC[C@H]4[C@]5([H])[C@@]4([H])CCC#CCC5)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for VH 032 amide-PEG3-BCN

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VH 032 amide-PEG3-BCN

For research use only

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