Catalog Number: 0757
Chemical Name: (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Biological Activity
Phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.
Technical Data
  • M.Wt:
    350.46
  • Formula:
    C22H26N2O2
  • Solubility:
    Soluble to 50 mM in ethanol and to 10 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    42971-09-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Effect of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle.
    Hagiwara et al.
    Biochem.Pharmacol., 1984;33:453
  3. Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons.
    Molnar and Erdo
    Eur.J.Pharmacol., 1995;273:303
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Vinpocetine include:

1 Citations: Showing 1 - 1

  1. Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.
    Authors: Lee Et al.
    EMBO Mol Med 2015;194:5990

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