VU 0357121

Key Product Details

Product Description

VU 0357121 is a positive allosteric modulator of mGlu₅ receptors (EC₅₀ = 33 nM). Binds to a site distinct from that bound by MPEP (Cat. No. 1212).

Product Specifications for VU 0357121

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0357121

The following data is based on the product molecular weight 305.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.28 mL	16.38 mL	32.75 mL
5 mM	0.66 mL	3.28 mL	6.55 mL
10 mM	0.33 mL	1.64 mL	3.28 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hammond Discovery of a novel chemical class of mGlu₅ allosteric ligands with distinct modes of pharmacology. ACS Chem.Neurosci. 2010 PMID: 20981342

Product Documents for VU 0357121