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VU 0357121

4437 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4437/10
4437/50
VU 0357121 | CAS No. 433967-28-3 | Group I mGluR Modulators
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Description: Positive allosteric modulator of mGlu5 receptors

Chemical Name: 4-Butoxy-N-(2,4-difluorophenyl)benzamide

Purity: ≥99%

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Biological Activity

Positive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Binds to a site distinct from that bound by MPEP (Cat. No. 1212).

Technical Data

M.Wt:
305.32
Formula:
C17H17F2NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
433967-28-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology.
    Hammond et al.
    ACS Chem.Neurosci., 2010;1:702

Product Datasheets

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VersaClone cDNA Plasmids

Human mGluR5 (NP_000833) VersaClone cDNA

RDC1064

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