VU 0409551

Catalog # Availability Size / Price Qty
5693/10
5693/50
Cat.No. 5693 - VU 0409551 | C20H17FN2O3 | CAS No. 1363281-27-9
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Description: Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable
Alternative Names: JNJ 46778212

Chemical Name: [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone

Purity: ≥98%

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Biological Activity

Selective mGlu5 positive allosteric modulator (EC50 = 260 nM). Selective for mGlu5 over other mGluR subtypes, as well as 66 other receptors and ion channels. Selectively potentiates mGlu5 signaling via Gαq. Exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Brain penetrant and orally available.

Technical Data

M.Wt:
352.36
Formula:
C20H17FN2O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1363281-27-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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