VUF 8430 dihydrobromide

Key Product Details

Product Description

VUF 8430 dihydrobromide is a high affinity (pK_i = 7.5), potent histamine H₄ receptor full agonist (pEC₅₀ = 7.3). Displays moderate affinity for H₃ receptors (pK_i = 6.0) and weak partial agonist activity at H₂ receptors.

Product Specifications for VUF 8430 dihydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VUF 8430 dihydrobromide

The following data is based on the product molecular weight 323.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.10 mL	15.48 mL	30.95 mL
5 mM	0.62 mL	3.10 mL	6.19 mL
10 mM	0.31 mL	1.55 mL	3.10 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lim Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H₄ receptor agonist. J.Med.Chem. 2006 PMID: 17154494
• Lim Phenylalanine 169 in the second extracellular loop of the human histamine H₄ receptor is responsible for the difference in agonist binding between human and mouse H₄ receptors. J.Pharmacol.Exp.Ther. 2008 PMID: 18635748
• Sterk The influence of guanidio and isothiourea groups in histaminergic compounds on H₂-activity. Agents Actions 1986 PMID: 2942013

Product Documents for VUF 8430 dihydrobromide