VX 745
Chemical Name: 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
Purity: ≥98%
Biological Activity
VX 745 is a highly potent and selective p38α inhibitor (IC50 = 10 nM). Also blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of VX 745 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The discovery of VX-745: a novel and selective p38α kinase inhibitor.
Duffy et al.
ACS Med.Chem.Lett., 2011;2:758 -
Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.
Bagley et al.
Bioorg.Med.Chem.Lett., 2007;17:5107 -
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
Goldstein et al.
J.Med.Chem., 2010;53:2345
Product Datasheets
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Citations for VX 745
The citations listed below are publications that use Tocris products. Selected citations for VX 745 include:
2 Citations: Showing 1 - 2
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Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro.
Authors: Singh Et al.
Hum Exp Toxicol 2018;37:521
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The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
Authors: Haas Et al.
PLoS Pathog 2013;9:e1003737
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