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VX 745

3915 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3915/10
3915/50
VX 745 | CAS No. 209410-46-8 | p38 Inhibitors
1 Image
Description: Potent and selective p38α inhibitor

Chemical Name: 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Highly potent and selective p38α inhibitor (IC50 = 10 nM). Also blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of VX 745 is reviewed on the chemical probes website.

Technical Data

M.Wt:
436.26
Formula:
C19H9Cl2F2N3OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
209410-46-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The discovery of VX-745: a novel and selective p38α kinase inhibitor.
    Duffy et al.
    ACS Med.Chem.Lett., 2011;2:758
  2. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.
    Bagley et al.
    Bioorg.Med.Chem.Lett., 2007;17:5107
  3. Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
    Goldstein et al.
    J.Med.Chem., 2010;53:2345

Product Datasheets

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Citations for VX 745

The citations listed below are publications that use Tocris products. Selected citations for VX 745 include:

2 Citations: Showing 1 - 2

  1. Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro.
    Authors: Singh Et al.
    Hum Exp Toxicol  2018;37:521
  2. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
    Authors: Haas Et al.
    PLoS Pathog  2013;9:e1003737

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