Highly potent and selective p38α
= 10 nM). Also blocks TNFα
production in LPS-stimulated HWB in vitro
= 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.
Bagley et al.
The discovery of VX-745: a novel and selective p38α kinase inhibitor.
Duffy et al.
ACS Med.Chem.Lett., 2011;2:758
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
Goldstein et al.
The citations listed below are publications that use Tocris products. Selected citations for VX 745 include:
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