Catalog Number: 3915
Chemical Name: 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
Biological Activity
Highly potent and selective p38α inhibitor (IC50 = 10 nM). Also blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of VX 745 is reviewed on the chemical probes website.
Technical Data
  • M.Wt:
    436.26
  • Formula:
    C19H9Cl2F2N3OS
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    209410-46-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.
    Bagley et al.
    Bioorg.Med.Chem.Lett., 2007;17:5107
  2. The discovery of VX-745: a novel and selective p38α kinase inhibitor.
    Duffy et al.
    ACS Med.Chem.Lett., 2011;2:758
  3. Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
    Goldstein et al.
    J.Med.Chem., 2010;53:2345
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VX 745 include:

1 Citations: Showing 1 - 1

  1. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
    Authors: Haas Et al.
    PLoS Pathog 2013;9:e1003737

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