Catalog Number: 3200
Alternate Names: Xanthine amine congener
Chemical Name: N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride
Biological Activity
Adenosine receptor antagonist (IC50 values are 1.8 and 114 nM at A1 and A2 receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo.
Technical Data
  • M.Wt:
    501.41
  • Formula:
    C21H28N6O4.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC)
    Morgan et al.
    Life Sci., 1989;45:719
  2. Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations.
    Sawmiller et al.
    Cardiovasc.Res., 1994;28:604
  3. Purification and characterization of the human adenosine A2A receptor functionally expressed in Escherichia coli.
    Wei? and Grisshammer
    Eur.J.Biochem., 2002;269:82
Citations:

The citations listed below are publications that use Tocris products. Selected citations for XAC include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods 2015;12:661
  2. Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.
    Authors: Kaster Et al.
    Hepatology 2015;112:7833
  3. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
    Authors: Kozma Et al.
    Biochem Pharmacol 2013;85:1171

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