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Xanthurenic acid

4120 Datasheet / COA / SDS
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4120/50
Xanthurenic acid | CAS No. 59-00-7 | Group II mGluR Activators
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Description: Selectively activates group II mGlu receptors

Chemical Name: 4,8-Dihydroxyquinoline-2-carboxylic acid

Purity: ≥98%

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Biological Activity

Shown to selectively activate group II mGlu receptors in transfected HEK293 cells at nanomolar concentrations. Attenuates cAMP formation in mouse cortical slices expressing mGlu2 and mGlu3 receptors.

Technical Data

M.Wt:
205.17
Formula:
C10H7NO4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
59-00-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Xanthurenic acid, a novel endogenous ligand for metabotropic glutamate receptors.
    Mauro et al.
    Program No. 643.1/F2. 2010 Neuroscience Meeting Pl, 2010;:2010 (Online)
  2. The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis.
    Han et al.
    J.Insect.Physiol., 2007;53:254

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VersaClone cDNA Plasmids

Human mGluR2 (NP_000830) VersaClone cDNA

RDC0989

Human mGluR3 (NP_000831) VersaClone cDNA

RDC1012

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