YM 90K hydrochloride

Key Product Details

Product Description

YM 90K hydrochloride is a selective AMPA receptor antagonist (K_i values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Product Specifications for YM 90K hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YM 90K hydrochloride

The following data is based on the product molecular weight 309.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.29 mL	161.46 mL	322.92 mL
0.5 mM	6.46 mL	32.29 mL	64.58 mL
1 mM	3.23 mL	16.15 mL	32.29 mL
5 mM	0.65 mL	3.23 mL	6.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Umemura Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia. Brain Res. 1997 PMID: 9409705
• Nakano A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils. Life Sci. 2001 PMID: 11589513
• Ohmori 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. J.Med.Chem. 1994 PMID: 8120865

Product Documents for YM 90K hydrochloride