Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50
values are 0.15, 0.76, 12.0 and 29.0 μ
M respectively). Putative GPR35 agonist.
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All Tocris products are intended for laboratory research use only.
Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
Christensen and Torphy
Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
Soderling et al.
Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.
Taniguchi et al.
FEBS Lett., 2006;580:5003
The citations listed below are publications that use Tocris products. Selected citations for Zaprinast include:
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