Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one
Biological ActivityPhosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.
Taniguchi et al.
FEBS Lett., 2006;580:5003
Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
Christensen and Torphy
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
Soderling et al.
Citations for Zaprinast
The citations listed below are publications that use Tocris products. Selected citations for Zaprinast include:
5 Citations: Showing 1 - 5
Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model.
Pharmacol Rep 2018;71:139
The antiallergic mast cell stabilizers lodox. and bufrolin as the first high and equipotent agonists of human and rat GPR35.
Authors: MacKenzie Et al.
Mol Pharmacol 2014;85:91
Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats.
Authors: Polcari Et al.
Proc Natl Acad Sci U S A 2013;27:338
Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
Authors: Zerani Et al.
J Endourol 2004;183:279
Assessing the emetic potential of PDE4 inhibitors in rats.
Authors: Robichaud Et al.
Br J Pharmacol 2002;135:113
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