Zaprinast

Catalog # Availability Size / Price Qty
0947/25
Zaprinast | CAS No. 37762-06-4 | Phosphodiesterase Inhibitors
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Description: GPR35 agonist

Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one

Purity: ≥99%

Product Details
Citations (5)
Supplemental Products
Reviews

Biological Activity

Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Technical Data

M.Wt:
271.28
Formula:
C13H13N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
37762-06-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
    Lugnier
    Pharmacol.Ther., 2006;109:366
  2. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.
    Taniguchi et al.
    FEBS Lett., 2006;580:5003
  3. Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
    Christensen and Torphy
    Annu.Rep.Med.Chem., 1994;29:185
  4. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
    Soderling et al.
    J.Biol.Chem., 1998;273:15553

Product Datasheets

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Citations for Zaprinast

The citations listed below are publications that use Tocris products. Selected citations for Zaprinast include:

5 Citations: Showing 1 - 5

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