Catalog Number: 0947
Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one
Biological Activity
Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.
Technical Data
  • M.Wt:
    271.28
  • Formula:
    C13H13N5O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    37762-06-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
    Christensen and Torphy
    Annu.Rep.Med.Chem., 1994;29:185
  2. Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
    Lugnier
    Pharmacol.Ther., 2006;109:366
  3. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
    Soderling et al.
    J.Biol.Chem., 1998;273:15553
  4. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.
    Taniguchi et al.
    FEBS Lett., 2006;580:5003
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Zaprinast include:

2 Citations: Showing 1 - 2
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  1. Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats.
    Authors: Polcari Et al.
    Proc Natl Acad Sci U S A 2013;27:338
  2. Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
    Authors: Zerani Et al.
    J Endourol 2004;183:279
Tocris Small Molecules
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TC-G 1001

4879  
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