Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one
Biological ActivityZaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.
Taniguchi et al.
FEBS Lett., 2006;580:5003
Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
Christensen and Torphy
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
Soderling et al.
Citations for Zaprinast
The citations listed below are publications that use Tocris products. Selected citations for Zaprinast include:
6 Citations: Showing 1 - 6
Mitochondrial remodeling and ischemic protection by G protein�coupled receptor 35 agonists.
Authors: Wyant Et al.
Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model.
Pharmacol Rep 2018;71:139
The antiallergic mast cell stabilizers lodox. and bufrolin as the first high and equipotent agonists of human and rat GPR35.
Authors: MacKenzie Et al.
Mol Pharmacol 2014;85:91
Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats.
Authors: Polcari Et al.
Proc Natl Acad Sci U S A 2013;27:338
Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
Authors: Zerani Et al.
J Endourol 2004;183:279
Assessing the emetic potential of PDE4 inhibitors in rats.
Authors: Robichaud Et al.
Br J Pharmacol 2002;135:113
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