TC-G 1001

Catalog # Availability Size / Price Qty
4879/10
4879/50
Cat.No. 4879 - TC-G 1001 | C17H11FN2O3S | CAS No. 494191-73-0
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Description: GPR35 agonist; more potent than zaprinast (Cat. No. 0947)

Chemical Name: 4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid

Purity: ≥98%

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Biological Activity

GPR35 agonist (pEC50 values are 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays respectively). Displays 1000-fold greater potency at human GPR35 receptors relative to mouse and rat GPR35 orthologs in an IP1 accumulation assay. More potent than zaprinast (Cat. No. 0947).

Technical Data

M.Wt:
342.34
Formula:
C17H11FN2O3S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
494191-73-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. High-throughput identification and characterization of novel, species-selective GPR35 agonists.
    Neetoo-Isseljee et al.
    J.Pharmacol.Exp.Ther., 2013;344:568

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