ZM 336372

Tocris Bioscience | Catalog # 1321

Potent, selective c-Raf inhibitor
Tocris Bioscience
Discontinued Product
1321 has been discontinued. View all Raf Kinase Inhibitors products.

Key Product Details

Description

Potent, selective c-Raf inhibitor
View all Raf Kinase Inhibitors »

Product Description

ZM 336372 is a potent, selective inhibitor of c-Raf in vitro (IC50 = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50 = 2 μM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μM).

Licensing Information

Sold with the permission of AstraZeneca Ltd

Product Specifications for ZM 336372

Molecular Weight

389.45

Formula

C23H23N3O3

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide

CAS Number

208260-29-1

PubChem ID

5311006

InChI Key

SCJNCDSAIRBRIA-DOFZRALJSA-N

SMILES

CN(C)C1=CC(=CC=C1)C(=O)NC1=CC=C(C)C(NC(=O)C2=CC=C(O)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions for ZM 336372

The following data is based on the product molecular weight 389.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for ZM 336372

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ZM 336372

For research use only

Customer Reviews for ZM 336372 (1)

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  • Used for Migration assays
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: A549 or MDAMB231
    Verified Customer | Posted 07/01/2020
    We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
    All MAPK inhibitors (ZM336372: c-RAF inhibitor; UO126: MEK1/MEK2 inhibitor, SB203580: p38 inhibitor) were used at 10 μM
    ZM 336372 1321

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