ZM 336372

Catalog # Availability Size / Price Qty
1321/10
1321/50
ZM 336372 | CAS No. 208260-29-1 | Raf Kinase Inhibitors
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Description: Potent, selective c-Raf inhibitor

Chemical Name: 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide

Purity: ≥99%

Product Details
Citations (4)
Reviews (1)

Biological Activity

ZM 336372 is a potent, selective inhibitor of c-Raf in vitro (IC50 = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50 = 2 μM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μM).

Technical Data

M.Wt:
389.45
Formula:
C23H23N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
208260-29-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca Ltd

Product Datasheets

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Citations for ZM 336372

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Used for Migration assays
By Anonymous on 07/01/2020
Application: Species: Human

All MAPK inhibitors (ZM336372: c-RAF inhibitor; UO126: MEK1/MEK2 inhibitor, SB203580: p38 inhibitor) were used at 10 μM

PMID: 25712213

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