Potent, selective inhibitor of c-Raf in vitro
= 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50
= 2 μ
M). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μ
M). Also available as part of the MAPK Cascade Inhibitor Tocriset™
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Sold with the permission of AstraZeneca Ltd
Paradoxical activation of Raf by a novel Raf inhibitor.
Hall-Jackson et al.
Down-regulation of intrinsic p-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species.
Wartenberg et al.
The citations listed below are publications that use Tocris products. Selected citations for ZM 336372 include:
Showing Results 1 - 3 of 3