ZMPSTE24 Antibody [Janelia Fluor® 669]

Novus Biologicals | Catalog # NB100-2388JF669

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Janelia Fluor 669

Antibody Source

Polyclonal Rabbit IgG
View all ZMPSTE24 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to a C-terminal portion of the human ZMPSTE24 protein sequence (between residues 400-475). [Swiss-Prot# O75844]

Localization

Integral membrane, primarily ER

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for ZMPSTE24 Antibody [Janelia Fluor® 669]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: ZMPSTE24

ZMPSTE24, also known as FACE1, is a zinc metalloprotease involved in the post-translational processing of Lamin A/C precursors. Specifically, ZMPSTE-24 proteolytically removes the C-terminal three residues of the farnesylated Lamin proteins.

FACE-1 is widely expressed, with the highest levels found in the kidney, prostate, testis and ovary.

Mutations in ZMPSTE24 have been associated with human diseases such as mandibuloacral dysplasia with type B lipodystrophy (MADB) and lethal tight skin contracture syndrome (LTSCS), often due to the accumulation of LMNA precursors. It is theorized that ZMPSTE24 may play an important role in human ageing, based on its association with LMNA.

Alternate Names

zona pellucida binding protein 2, zona pellucida-binding protein 2, ZPBP-like protein, ZPBPLMGC41930

Gene Symbol

ZMPSTE24

Additional ZMPSTE24 Products

Product Documents for ZMPSTE24 Antibody [Janelia Fluor® 669]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for ZMPSTE24 Antibody [Janelia Fluor® 669]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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