Catalog Number: 1094
Chemical Name: 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester
Biological Activity
A non benzodiazepine BZR agonist, with little difference in affinity for the BZ1 and BZ2 subtypes; however its CNS effects differ from those of other BZR ligands and this may be due to interaction with a different subunit.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as a hypnotic.
    Goa and Heel
    Drugs, 1986;32:48
  2. Potentiation of γ-aminobutyric acid induced chloride currents by various benzodiazepine site agonists with the α1γ2, β2γ2 and α1β2γ2 subtypes of cloned γ-aminobutyric acid type A receptors.
    Im et al.
    Mol.Pharmacol., 1993;44:866
  3. Heterogeneous distribution of benzodiazepine receptors among rat neostriatal neurones.
    Munakata et al.
    Br.J.Pharmacol., 1996;118:820

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