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3 results for "CDK4 Subfamily Inhibitors" in Products
CDK4 Subfamily Inhibitors
CDK4 and CDK6
The CDK 4 subfamily of cyclin-dependent kinases consists of CDK4 and CDK6, which function interchangeably in most cell types during G1 phase of the cell cycle. Both CDK4 and CDK6 bind cyclin D, leading to phosphorylation and inactivation of retinoblastoma protein (Rb) and transcription of E2F target genes, which includes those responsible for cell cycle progression.
Cyclin D interacts with the N-terminal lobe of CDK4; however, no conformational change is induced by its binding ...
Potent cdk4 and cdk6 inhibitor; brain penetrant
| Alternate Names: | Palbociclib |
| Chemical Name: | 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt |
| Purity: | ≥98% |
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SETD8 inhibitor; also CDK4 inhibitor
| Chemical Name: | 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione |
| Purity: | ≥98% |
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Dual cdk4/cdk6 inhibitor; orally bioavailable
| Alternate Names: | LEE-011 |
| Chemical Name: | 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Purity: | ≥98% |
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