Chemical Name: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Biological Activity Inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.
Soluble to 20 mM in DMSO and to 5 mM in ethanol
Store at +4°C
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