Ryuvidine

  ( 1 citations )    
Product Datasheet
Catalog Number:2609
Chemical Name:2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Product Details
Citations (1)
Reviews
Biological Activity
Inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.
Technical Data
  • M.Wt:
    284.33
  • Formula:
    C15H12N2O2S
  • Solubility:
    Soluble to 20 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    265312-55-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ryuvidine include:

1 Citations: Showing 1 - 1

  1. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.
    Authors: FitzGerald Et al.
    PLoS One  2014;9:e98891

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