Ryuvidine

Catalog # Availability Size / Price Qty
2609/10
2609/50
Ryuvidine | CAS No. 265312-55-8 | Lysine Methyltransferase Inhibitors
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Description: SETD8 inhibitor; also CDK4 inhibitor

Chemical Name: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.

Technical Data

M.Wt:
284.33
Formula:
C15H12N2O2S
Solubility:
Soluble to 20 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
265312-55-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule inhibitors of SETD8 with cellular activity.
    Blum et al.
    ASC.Chem.Biol. [Epub ahead of print], 2014;9:2471
  2. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.
    Ryu et al.
    Bioorg.Med.Chem.Lett., 2000;10:461

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Citation for Ryuvidine

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