Chemical Name: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Biological ActivityRyuvidine is an inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule inhibitors of SETD8 with cellular activity.
Blum et al.
ASC.Chem.Biol. [Epub ahead of print], 2014;9:2471
5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.
Ryu et al.
Citation for Ryuvidine
The citations listed below are publications that use Tocris products. Selected citations for Ryuvidine include:
1 Citation: Showing 1 - 1
A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.
Authors: FitzGerald Et al.
PLoS One 2014;9:e98891
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